phospho-STAT2 (Tyr689) Antibody | EMD Millipore 07-224 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-STAT2 (Tyr689) Antibody

catalog :

07-224

quantity :

200 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse

application :

western blot, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig s4f	Liu Y, You Y, Lu Z, Yang J, Li P, Liu L, et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science. 2019;365:1171-1176 pubmed publisher
western blot; human; 1:2000; loading ...; fig 3a	Eletto D, Burns S, Angulo I, Plagnol V, Gilmour K, Henriquez F, et al. Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection. Nat Commun. 2016;7:13992 pubmed publisher
western blot; human; loading ...; fig 3h	Baron L, Paatero A, Morel J, Impens F, Guenin Macé L, Saint Auret S, et al. Mycolactone subverts immunity by selectively blocking the Sec61 translocon. J Exp Med. 2016;213:2885-2896 pubmed
western blot; mouse; 1:1000; fig 4	Speer S, Li Z, Buta S, Payelle Brogard B, Qian L, Vigant F, et al. ISG15 deficiency and increased viral resistance in humans but not mice. Nat Commun. 2016;7:11496 pubmed publisher

product information

Catalog Number :

07-224

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-STAT2 (Tyr689) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P52630

Host Name :

Rabbit

Antigen :

phospho-STAT2 (Tyr689)

Conjugate :

Affinity Purified

Isotype :

IgG

Product Description :

Anti-phospho-STAT2 (Tyr689) Antibody

Cross Reactivity :

Human;Mouse

Background :

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia. STAT2 (113 kDa), originally purified from the nuclei of a-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta. Knockout mice with a targeted disruption of STAT2 exhibit greater susceptibility to viral infection and altered responses to Type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via assocations with receptor-bound Jak kinases.

Immunogen :

KLH-conjugated linear peptide corresponding to mouse STAT2 phosphorylated at Tyr689.

Specificity :

Recognizes STAT2 phosphorylated at tyrosine 689.

Package Size :

200 μL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt