Grb10 Antibody | EMD Millipore 07-2182 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Grb10 Antibody

catalog :

07-2182

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken, cow

application :

western blot

product information

Catalog Number :

07-2182

Subcategory :

Cell Signaling

Product Name :

Anti-Grb10 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q13322

Host Name :

Rabbit

Antigen :

Grb10

Conjugate :

Affinity Purified

Product Description :

Anti-Grb10 Antibody

Cross Reactivity :

Human;Mouse;Rat;Bovine;Pig;Chicken

Background :

Grb10 (insulin receptor-binding protein Grb-IR) is a ubiquitous adapter protein which is expressed in both fetal and adult tissues. It is a multidomain protein that interacts with a wide array of cellular targets; the PH domain allows interaction with several subtypes of phosphoinositides; the Ras-associating domain binds a wide variety of Ras GTPases; and the SH domain facilitates binding to membrane-bound tyrosine kinase receptors which link Grb10 to different signaling pathways. Most notably, Grb10 associates with the insulin receptor at phosphotyrosine residues via its C-terminal BPS (between PH and SH) domain and inhibits the enzymatic activity of the insulin receptor. Grb10 also acts downstream of the insulin receptor pathway to inhibit activation of AKT-1. In addition, Grb10 suppresses Wnt signalling by binding to the low-density lipoprotein receptor. In fetal tissues, Grb10 may play inhibit growth and placental size.

ALT Names :

Growth factor receptor-bound protein 10;GRB10 adapter protein;Insulin receptor-binding protein Grb-IR

Immunogen :

KLH-conjugated linear peptide corresponding to human Grb10.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt