PCNA Antibody | EMD Millipore 07-2162 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PCNA Antibody

catalog :

07-2162

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs, chimpanzee

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:200; fig 3	Skardal A, Devarasetty M, Forsythe S, Atala A, Soker S. A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening. Biotechnol Bioeng. 2016;113:2020-32 pubmed publisher

product information

Catalog Number :

07-2162

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-PCNA Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P12004

Host Name :

Rabbit

Antigen :

PCNA

Conjugate :

Purified

Product Description :

Anti-PCNA Antibody

Cross Reactivity :

Human;Mouse;Rat;Chimpanzee

Background :

Proliferating cell nuclear antigen (PCNA) belongs to the DNA sliding clamp family and is comprised of three identical monomers forming a heterodimer. Due to its unique structure, PCNA is able to increase the processivity of DNA polymerase delta by using its outer domains to be involved in protein-protein interaction while still tethered to and freely sliding along the DNA. PCNA is a critical regulatory component in the onset of leading strand DNA replication and the termination of lagging strand synthesis. Studies have also indicated a role for PCNA in the recruitment and regulation of MMR pathway repair proteins. PCNA is also able to interact with a wide variety of cell cycle proteins and serves to coordinate several proteins participating in DNA processes, such as apoptosis.

ALT Names :

proliferating cell nuclear antigen;cyclin;DNA polymerase delta auxiliary protein;Cyclin

Immunogen :

GST-tagged recombinant protein corresponding to human PCNA.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt