phospho-Histone H2B (Ser14) Antibody | EMD Millipore 07-191 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Histone H2B (Ser14) Antibody

catalog :

07-191

quantity :

200 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

citations: 1

Reference
Pefani D, Tognoli M, Pirincci Ercan D, Gorgoulis V, O Neill E. MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B. EMBO J. 2018;37: pubmed publisher

product information

Catalog Number :

07-191

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-Histone H2B (Ser14) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8N257

Host Name :

Rabbit

Antigen :

phospho-Histone H2B (Ser14)

Conjugate :

Serum

Isotype :

IgG

Product Description :

Anti-phospho-Histone H2B (Ser14) Antibody

Cross Reactivity :

Human

Background :

Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The amino-terminal tails of core histones undergo various posttranslational modifications, including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, on gene expression.

ALT Names :

H2BS14P;Histone H2B (phospho S14);H2B type 12;histone 3, H2bb;histone H2B;v

Immunogen :

KLH-conjugated, synthetic peptide corresponding to amino acids 6-16 of human histone H2B (C-SAPAPKKG[pS]KK).

Specificity :

Recognizes phospho-Histone H2B (Ser14), Mr 15 kDa.

Package Size :

200 µL

Uses :

ELISA;Immunocytochemistry;Immunohistochemistry;Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.