phospho-JNK (Thr183/Tyr185, Thr221/Tyr223) Antibody | EMD Millipore 07-175 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-JNK (Thr183/Tyr185, Thr221/Tyr223) Antibody

catalog :

07-175

quantity :

200 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, dogs, chicken, bovine

application :

western blot, immunoprecipitation

citations: 1

Reference
Fong Y, Wu C, Chang K, Chen B, Chou W, Tseng C, et al. Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells. Cancer Cell Int. 2017;17:37 pubmed publisher

product information

Catalog Number :

07-175

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-JNK (Thr183/Tyr185, Thr221/Tyr223) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P45983

Host Name :

Rabbit

Antigen :

phospho-JNK (Thr183/Tyr185

Conjugate :

Affinity Purified

Isotype :

IgG

Product Description :

Anti-phospho-JNK (Thr183/Tyr185, Thr221/Tyr223) Antibody

Cross Reactivity :

Mouse;Human;Rat;Canine;Xenopus;Chicken;Bovine;Horse

Background :

JNK1(MAPK8) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-α) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. The JNK pathway is critically involved in diabetes and levels are abnormally elevated in obesity. The cell-permeable JNK inhibitory peptide may have promise as a therapeutic agent for diabetes.

ALT Names :

JNK1 alpha protein kinase;JNK1 beta protein kinase;JUN N-terminal kinase;Stress-activated protein kinase JNK1;Stress-activated protein kinase JNK1;mitogen-activated protein kinase 8;mitogen-activated protein kinase 8 isoform JNK1 alpha1;mitogen-activated protein kinase 8 isoform JNK1 alpha1;protein kinase JNK1

Immunogen :

KLH-conjugated linear peptide corresponding to human JNK phosphorylated at Thr183/Tyr185 and Thr221/Tyr223.

Specificity :

This antibody recognizes JNK when phosphorylated at Thr183/Tyr185 and Thr221/Tyr223 .

Package Size :

200 μg

Uses :

Western Blotting;Enzyme Assay;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt