phospho-β Catenin (Ser37) Antibody | EMD Millipore 07-1651 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-β Catenin (Ser37) Antibody

catalog :

07-1651

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, chicken

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...; fig 3b	Morris J, Moseley V, Cabang A, Coleman K, Wei W, Garrett Mayer E, et al. Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXR? expression in human colon cancer cells. Oncotarget. 2016;7:35313-26 pubmed publisher

product information

Catalog Number :

07-1651

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-β Catenin (Ser37) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P35222

Host Name :

Rabbit

Antigen :

phospho-β Catenin (Ser37)

Conjugate :

Purified

Product Description :

Anti-phospho-β Catenin (Ser37) Antibody

Cross Reactivity :

Human;Mouse;Rat;Chicken;Xenopus

Background :

Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer. After phosphorylation, beta catenin is rapidly degraded into various fragments over time (Giuseppina, T., 1998).

ALT Names :

catenin (cadherin-associated protein), beta 1 (88kD);catenin (cadherin-associated protein), beta 1, 88kDa ;catenin beta-1

Immunogen :

KLH-conjugated synthetic linear peptide corresponding to phosphorylated beta catenin.

Specificity :

This antibody recognizes β catenin phosphorylated at Ser37. Depending on the type of treatment and the amount of time elapsed after the phosphorylation event, the antibody will detect both full length phospho-β catenin (Ser37), as well as the degraded/fragmented form of phospho-β catenin (S37) that results immediately after phosphorylation (Giuseppina, 1998).

Package Size :

100 μL

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8ºC from date of receipt.