HIF-1-alpha Antibody, hydroxyproline (Pro402) | EMD Millipore 07-1585 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

HIF-1-alpha Antibody, hydroxyproline (Pro402)

catalog :

07-1585

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine, zebrafish

application :

western blot

citations: 1

Reference
Koukourakis M, Giatromanolaki A, Zois C, Kalamida D, Pouliliou S, Karagounis I, et al. Normal tissue radioprotection by amifostine via Warburg-type effects. Sci Rep. 2016;6:30986 pubmed publisher

product information

Catalog Number :

07-1585

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-HIF-1-alpha Antibody, hydroxyproline (Pro402)

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q16665

Host Name :

Rabbit

Antigen :

HIF-1-alpha

Conjugate :

Affinity Purified

Product Description :

Anti-HIF-1-alpha Antibody, hydroxyproline (Pro402)

Cross Reactivity :

Human

Background :

Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1α, HIF-1β (also designated Arnt 1), EPAS-1 (also designated HIF-2α) and HIF-3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with HIF-1β to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1α dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1α independent. EPAS-1 and HIF-3α have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia.

ALT Names :

Hypoxia-inducible factor 1-alpha;HIF-1-alpha;HIF1-alpha;ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1;Class E basic helix-loop-helix protein 78;bHLHe78;Member of PAS protein 1;PAS domain-containing protein 8

Immunogen :

KLH-conjugated linear peptide corresponding to the ODD region of human HIF-1-alpha.

Specificity :

This antibody recognizes HIF-1-alpha at the ODD region.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt