monomethyl Histone H4 (Lys20) Antibody | EMD Millipore 07-1570 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

monomethyl Histone H4 (Lys20) Antibody

catalog :

07-1570

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, neutralization, chromatin immunoprecipitation

product information

Catalog Number :

07-1570

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-monomethyl Histone H4 (Lys20) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P62805

Host Name :

Rabbit

Antigen :

monomethyl Histone H4 (Lys20)

Conjugate :

Affinity Purified

Product Description :

Anti-monomethyl Histone H4 (Lys20) Antibody

Cross Reactivity :

Human

Background :

Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histones modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). Methylation of histone H4 at lysine 20 has been implicated in transcriptional activation, gene silencing, heterochromatin formation, mitosis, and DNA repair. Histone H4 is progressively methylated at Lys20 during the G(2), M, and G(1) phases of the cell cycle, and methylation of H4Lys20 is a marker for heterochromatin. In mammals, the female X chromosome is coated by the Xist RNA, which is critical for silencing, and is marked mainly by methylation of H3Lys9, H3Lys27 and H4Lys20.

ALT Names :

H4K20me1;Histone H4 (mono methyl K20);H4 histone family, member A;histone 1, H4a;histone cluster 1, H4a

Immunogen :

KLH-conjugated, linear synthetic peptide corresponding to amino acids 15-24 (AKRHR[me1K]VLRD-C) of human Histone H4.

Specificity :

Recognizes monomethylated Histone H4 (Lys20), Mr 11 kDa.

Package Size :

100 µg

Uses :

Western Blotting;Dot Blot;Chromatin Immunoprecipitation (ChIP);Peptide Inhibition Assay

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.