Calcineurin Aα Antibody | EMD Millipore 07-1492 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Calcineurin Aα Antibody

catalog :

07-1492

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; rat	Furman J, Sompol P, Kraner S, Pleiss M, Putman E, Dunkerson J, et al. Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury. J Neurosci. 2016;36:1502-15 pubmed publisher
	Zemel B, Muqeem T, Brown E, Goulao M, Urban M, Tymanskyj S, et al. Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons. J Neurosci. 2017;37:8256-8272 pubmed publisher
	Sompol P, Furman J, Pleiss M, Kraner S, Artiushin I, Batten S, et al. Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in A?-Bearing Mice. J Neurosci. 2017;37:6132-6148 pubmed publisher

product information

Catalog Number :

07-1492

Subcategory :

Cell Signaling

Product Name :

Anti-Calcineurin Aα Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q08209

Host Name :

Rabbit

Antigen :

Calcineurin Aα

Conjugate :

Affinity Purified

Product Description :

Anti-Calcineurin Aα Antibody

Cross Reactivity :

Mammals;Human;Rat;Mouse

Background :

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal transduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin's multifunctional capabilities in the regulation of calcium signaling. The Aα form of calcineurin is a major catalytic subunit gene isoform of calcineurin in most tissues that allows differentiation of Aα from the Aβ and Aγ isoforms.

ALT Names :

NFAT transcription complex cytosolic component ;nuclear factor of activated T-cells, cytoplasmic,;calcineurin-dependent 1 ;nuclear factor of activated T-cells, cytosolic component 1

Immunogen :

KLH-conjugagted synthetic peptide corresponding to Calcineurin Aα.

Specificity :

This antibody recognizes the Aα form of calcineurin.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will remain unfrozen. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.