Cdc42 Antibody | EMD Millipore 07-1466 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cdc42 Antibody

catalog :

07-1466

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

African green monkey, human

application :

western blot, immunocytochemistry

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig s5f	Nakanishi M, Mitchell R, Benoit Y, Orlando L, Reid J, Shimada K, et al. Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Cell. 2019;177:910-924.e22 pubmed publisher
western blot; human; loading ...; fig 6a	Lee C, Cheng Y, Chang C, Lin C, Chang J. Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption. Sci Rep. 2018;8:17477 pubmed publisher
western blot; African green monkey; loading ...; fig 4c	Villarroel Campos D, Henríquez D, Bodaleo F, Oguchi M, Bronfman F, Fukuda M, et al. Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B. J Neurosci. 2016;36:7298-313 pubmed publisher
	Bonfim Melo A, Ferreira d, Mortara R. Rac1/WAVE2 and Cdc42/N-WASP Participation in Actin-Dependent Host Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. Front Microbiol. 2018;9:360 pubmed publisher
	Horibata S, Rogers K, Sadegh D, Anguish L, McElwee J, Shah P, et al. Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. BMC Cancer. 2017;17:378 pubmed publisher

product information

Catalog Number :

07-1466

Subcategory :

Cell Signaling

Product Name :

Anti-Cdc42 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P60953

Host Name :

Rabbit

Antigen :

Cdc42

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Cdc42 Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

cdc42 is a member of the Rho family of small GTP-binding proteins, and plays roles in cytoskeletal Actin organization as well as transformation. Rac is activated downstream of cdc42, or independently by Ras signaling, and in turn Rac stimulates Rho. Activation of cdc42 stimulates filopodia formation, whereas Rac results in the formation of lamellipodia, and Rho stimulates formation of actin stress fibers. Effectors of the cdc42/Rac pathway include NADPH Oxidase (Phox) and the SAPK1/JNK family of kinases. The latter pathway is activated by the PAK kinases, which are direct targets of cdc42.

ALT Names :

G25K;GTP-binding Protein

Immunogen :

Synthetic peptide corresponding to amino acids 130-141 of human Cdc42 (AKNKQKPITPET-C).

Specificity :

Recognizes Cdc42, does not cross react with Rac1. Cdc42 is a member of the Rho family of small GTPases. Small GTPases act as molecular switches in regulating a variety of biological response pathways by cycling from the GDP-bound (inactive) and GTP-bound (active) states. Cdc42 induces the formation of filopodia. Cdc42 can activate Rac (consequently, filopodia are intimately associated with lamellipodia.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable at 2-8°C in undiluted aliquots for up to 6 months from date of receipt.