ROCK-1/2 Antibody | EMD Millipore 07-1458 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ROCK-1/2 Antibody

catalog :

07-1458

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 2c	Rath N, Morton J, Julian L, Helbig L, Kadir S, McGhee E, et al. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Mol Med. 2017;9:198-218 pubmed publisher

product information

Catalog Number :

07-1458

Subcategory :

Cell Structure

Product Name :

Anti-ROCK-1/2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q13464

Host Name :

Rabbit

Antigen :

ROCK-1/2

Conjugate :

Affinity Purified

Product Description :

Anti-ROCK-1/2 Antibody

Cross Reactivity :

Human;Mouse

Background :

Rho-Associated Kinase (Rho-Kinase or ROK) has been classified into two isoforms: ROKα/ROCK-II and ROKβ/ROCK-I. These large cellular proteins (150-160 kDa), have been reported to be involved in the formation of stress fibers, focal adhesions and cardiac hypertonic responses. Current research suggests that ROK of smooth muscle may be involved in the contractile process via phosphorylation of MYPT1 and Myosin. The serine-threonine kinase ROCK-1 is a down-stream effector of Rho, and is involved in signal transduction pathways that regulate cell morphology, motility, and tumor progression through the reorganization of the actin cytoskeleton.

ALT Names :

Renal carcinoma antigen NY-REN-35 ;Rho kinase ;Rho-associated, coiled-coil containing protein kinase 1;Rho-associated, coiled-coil-containing protein kinase 1;p160 ROCK-1

Immunogen :

Synthetic peptide corresponding to human ROCK-1, 90.5% homology with ROCK-2

Specificity :

This antibody recognizes ROCK-1 and ROCK-2.

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.