Beta Pix, SH3 Domain | EMD Millipore 07-1450-I product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Beta Pix, SH3 Domain

catalog :

07-1450-I

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:200; loading ...; fig 4b western blot; human; 1:1000; loading ...; fig 4b immunocytochemistry; rat; 1:200; loading ...; fig 4b	Donnelly S, Cabrera R, Mao S, Christin J, Wu B, Guo W, et al. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017;216:4331-4349 pubmed publisher
	Ramirez San Juan G, Oakes P, Gardel M. Contact guidance requires spatial control of leading-edge protrusion. Mol Biol Cell. 2017;28:1043-1053 pubmed publisher

product information

Catalog Number :

07-1450-I

Subcategory :

Cell Signaling

Product Name :

Anti-Beta Pix, SH3 Domain

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q14155

Host Name :

Rabbit

Antigen :

ARHGEF7

Conjugate :

Affinity Purified

Purification Method :

Affinity purified

Product Description :

Anti-Beta Pix, SH3 Domain

Cross Reactivity :

Human, Mouse, Rat

Background :

Beta-Pix (ARHGEF7, βPix, COOL) is a Rho guanine nucleotide exchange factor (GEF). Beta-Pix is a p21-activated protein kinase (PAK)-interacting exchange factor (Pix, COOL, p85SPR) that has been identified as a putative guanine nucleotide exchange factor (GEF) for Rac/Cdc42. The variants of Beta-Pix isoforms exhibit different tissue distributions. Beta-Pix-a is expressed ubiquitously in all the tissues examined, and other isoforms are expressed mainly in the central nervous system. PAK, a Ser/Thr kinase, is an important mediator of Rho family activity interacts with Beta-Pix at the SH3 domain of Beta-Pix though its proline rich region. This interaction is thought to affect the GTP hydrolysis rate of Rac and Cdc42.

ALT Names :

Rho guanine nucleotide exchange factor 7, Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85

Immunogen :

GST-tagged recombinant protein corresponding to the SH3 domain of human Beta-Pix, SH3 Domain.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt