SGLT-1 (Sodium Glucose Co-transporter-1) Antibody | EMD Millipore 07-1417 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SGLT-1 (Sodium Glucose Co-transporter-1) Antibody

catalog :

07-1417

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
Madunić I, Breljak D, Karaica D, Koepsell H, Sabolic I. Expression profiling and immunolocalization of Na+-D-glucose-cotransporter 1 in mice employing knockout mice as specificity control indicate novel locations and differences between mice and rats. Pflugers Arch. 2017;469:1545-1565 pubmed publisher
Yonamine C, Pinheiro Machado E, Michalani M, Freitas H, Okamoto M, Correa Giannella M, et al. Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory. Nutr Metab (Lond). 2016;13:44 pubmed publisher
Oliveira T, Candeia Medeiros N, Cavalcante AraÃºjo P, Melo I, FÃ¡varo PÃpi E, FÃ¡tima L, et al. SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation. Sci Rep. 2016;6:21752 pubmed publisher

product information

Catalog Number :

07-1417

Subcategory :

Cell Signaling

Product Name :

Anti-SGLT-1 (Sodium Glucose Co-transporter-1) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8C3K6

Host Name :

Rabbit

Antigen :

SGLT-1 (Sodium Glucose Co-transporter-1)

Conjugate :

Serum

Isotype :

IgG

Product Description :

Anti-SGLT-1 (Sodium Glucose Co-transporter-1) Antibody

Cross Reactivity :

Canine;Human;Mouse;Pig;Rat;Rabbit;Feline;Avian;Reptile

Background :

The kidneys play a major role in the regulation of blood glucose. Although kidney nephrons indiscriminatly filter about 180g of glucose per day from the blood, most is reabsorbed actively in the proximal convoluted tubule by a Na+/Gl co-transport (ratio 2:1) mechanism (SGLT). Typically, glucose is first reabsorbed by these transporters, which reside within the brush-border epithelia of the PCT cells. The glucose is then transported out of the cell across the basolateral membranes by a facilitated diffusion sugar transporter (GLUTs). At least three members of SGLT's (SGLT1-3) have been cloned and characterized from various species. SGLT1-3 genes code for protein of approximately 659-672 residues, with both N and C termini predicted to be extracellular. There is approximately 60-70% homology between the 3 forms. SGLT1 does not discriminate a-MDG, glucose and galactose, while SGLT2 and 3 do not transport D-galactose efficiently. SGLT1 is an integral membrane protein expressed in proximal convoluted tubule Sq1 segments of the kidney (outer renal medulla) and in the intestine.

ALT Names :

Sodium/glucose cotransporter 1;Solute carrier family 5 member 1;Solute carrier family 5 (sodium/glucose cotransporter), member 1;Solute carrier family 5 (sodium/glucose transporter), member 1

Immunogen :

Synthetic peptide corresponding to amino acids 402-420 in the cytoplasmic region of SGLT-1 of mouse/rabbit small intestine.

Specificity :

Recognizes SGLT-1.

Package Size :

100 μL

Uses :

Western Blotting;Immunohistochemistry (Paraffin);ELISA

Storage :

Stable for 1 year at -20°C from date of receipt in undiluted aliquots. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.