GSK-3b Antibody, a.a. 335-349 | EMD Millipore 07-1413 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GSK-3b Antibody, a.a. 335-349

catalog :

07-1413

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

product information

Catalog Number :

07-1413

Subcategory :

Cell Signaling

Product Name :

Anti-GSK-3b Antibody, a.a. 335-349

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P49841

Host Name :

Rabbit

Antigen :

GSK-3b

Conjugate :

Affinity Purified

Isotype :

IgG

Product Description :

Anti-GSK-3b Antibody, a.a. 335-349

Cross Reactivity :

Rat;Human;Mouse;Bovine

Background :

GSK3 (Glycogen Synthase Kinase 3) differs from most serine/threonine kinases in that it is active in the absence of the action of signaling pathways. Two isoforms exist, GSK3α and GSK3β. The function of GSK3 is to phosphorylate Glycogen Synthase and thereby inactivate it. Insulin action stimulates the PI3 Kinase pathway, resulting in Akt activation, which phosphorylates and inactivates GSK3. Glycogen Synthase is then rapidly dephosphorylated and activated. Other GSK3 substrates include Jun (on inhibitory sites), and eIF2B. Phosphorylation of Tau by GSK3 may relate to development of Alzheimer's disease. Phosphorylation state-specific antibodies directed against the Akt site (Ser21) on GSK3 are suitable for surrogate assays of the activation state of the pathway.

Immunogen :

Rat GSK3 beta synthetic peptide (aa. 335-349), conjugated to KLH. This sequence is 100% identical to human GSK3 beta.

Specificity :

This antibody detects a strong 47 kDa protein, corresponding to the expected molecular mass of GSK3 beta.

Package Size :

50 µg

Uses :

Western Blotting;Immunoprecipitation;Immunohistochemistry (Paraffin)

Storage :

Stable at –20 ºC for up to one year from date of receipt. Product may be stored at for 2-4 weeks at 2º-8ºC. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.