phospho-Smad3 (Ser423/425) Antibody | EMD Millipore 07-1389 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Smad3 (Ser423/425) Antibody

catalog :

07-1389

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig s1	Dhawan S, Dirice E, Kulkarni R, Bhushan A. Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. Diabetes. 2016;65:1208-18 pubmed publisher

product information

Catalog Number :

07-1389

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-Smad3 (Ser423/425) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P84022

Host Name :

Rabbit

Antigen :

phospho-Smad3 (Ser423/425)

Product Description :

Anti-phospho-Smad3 (Ser423/425) Antibody

Cross Reactivity :

Mouse;Mink;Human;Rat

Background :

Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmits TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5 and 8, the common-mediator Smad (co-Smad), Smad4, and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses. Following stimulation by TGF-β, Smad2 and Smad3 become phosphorylated at their carboxyl termini (Ser465 and 467 on Smad2; Ser423 and 425 on Smad3) by TGF-β Receptor I. Phosphorylated Smad 2/3 can complex with Smad4, translocate to the nucleus and regulate gene expression.

ALT Names :

MAD, mothers against decapentaplegic homolog 3;MAD, mothers against decapentaplegic homolog 3 (Drosophila);Mothers against DPP homolog 3 ;SMA- and MAD-related protein 3;SMAD 3 ;SMAD family member 3;SMAD, mothers against DPP homolog 3;SMAD, mothers against DPP homolog 3 (Drosophila);mad homolog JV15-2;mad protein homolog ;mothers against decapentaplegic homolog 3

Immunogen :

KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser423/425 of human Smad3.

Specificity :

Detects phosphorylated Smad3 (Ser423 and Ser425).

Package Size :

100 μL

Uses :

Western Blotting

Storage :

Stable for 2 years at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.