ECT2 Antibody | EMD Millipore 07-1364 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ECT2 Antibody

catalog :

07-1364

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunocytochemistry

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:50; loading ...; fig s3g	Priya R, Liang X, Teo J, Duszyc K, Yap A, Gomez G. ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens. Mol Biol Cell. 2017;28:12-20 pubmed publisher
immunocytochemistry; human; 1:100; loading ...	van de Ven R, de Groot J, Park D, van Domselaar R, de Jong D, Szuhai K, et al. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nat Commun. 2016;7:13874 pubmed publisher
western blot; human; 1:1000; fig s6	Heemskerk N, Schimmel L, Oort C, van Rijssel J, Yin T, Ma B, et al. F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling. Nat Commun. 2016;7:10493 pubmed publisher

product information

Catalog Number :

07-1364

Subcategory :

Cell Signaling

Product Name :

Anti-ECT2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q9H8V3

Host Name :

Rabbit

Antigen :

ECT2

Conjugate :

Affinity Purified

Product Description :

Anti-ECT2 Antibody

Cross Reactivity :

Human;Rat;Mouse;Pig;Bovine;Opossum;Monkey

Background :

Epithelial cell-transforming sequence 2 oncogene (ECT2) is a guanine nucleotide exchange factor or GEF that belongs to the Dbl family of Rho GEFs. ECT2 is composed of 2 BRCT domains within the N-terminus, a DBL-homology domain, and a PH domain. Studies have shown ECT2 to localize to both the cell cortex and central spindles, and that it is a crucial part of cleavage furrow formation during cytokenises. Overexpression of cleaved ECT2, containing only the N-terminal domain, has been shown to cause multinucleation. As a GEF it has been shown to bind specifically to Rac proteins, RhoA, and RhoC.

ALT Names :

epithelial cell transforming sequence 2 oncogene;Epithelial cell-transforming sequence 2 oncogene;protein ECT2

Immunogen :

KLH-conjugated linear peptide corresponding to human ECT2 at the C-terminus.

Specificity :

This antibody recognizes ECT2 at the C-terminus.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt