PP2A-B’ (B56) Antibody | EMD Millipore 07-1221 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PP2A-B’ (B56) Antibody

catalog :

07-1221

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 2l	Fan L, Liu M, Guo M, Hu C, Yan Z, Chen J, et al. FAM122A, a new endogenous inhibitor of protein phosphatase 2A. Oncotarget. 2016;7:63887-63900 pubmed publisher

product information

Catalog Number :

07-1221

Subcategory :

Cell Signaling

Product Name :

Anti-PP2A-B’ (B56) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q15257

Host Name :

Rabbit

Antigen :

PP2A-B’ (B56)

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-PP2A-B’ (B56) Antibody

Cross Reactivity :

Bovine;Human;Mouse;Rat

Background :

PP2A is a heterotrimeric type 2 Ser/Thr phosphatase, composed of a structural subunit (A), a regulatory subunit (B), and a catalytic subunit (C). The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. There are multiple isotypes (encoded by distinct genes) of the B subunit, grouped into three families: B/PR55, B'/PR61, and B''/PR72 . The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B' (or B56) family consists of at least seven splice variants derived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals. PTPA is a member of the B' family that is required for activation of PP2A by an undefined mechanism. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and its high sensitivity to Okadaic Acid. It is also thought to be the principal downmodulator of Ser/Thr kinase cascades.

ALT Names :

PP2A phosphatase activator;PP2A, subunit B' ;PP2A, subunit B', PR53 isoform ;Phosphotyrosyl phosphatase activator;protein phosphatase 2A activator, regulatory subunit 4;protein phosphatase 2A, regulatory subunit B' ;protein phosphatase 2A, regulatory subunit B' (PR 53)

Immunogen :

The immunogen used for the purified peptide conjugated to KLH corresponds to the sequence NH2-Val-Ser-Ser-Pro-His-Phe-Gln-Val-Ala-Glu- Arg-Ala-Leu-Tyr-COOH.

Specificity :

This antibody is specific to PP2A-B’ subunits.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.