Tip60 Antibody | EMD Millipore 07-038 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tip60 Antibody

catalog :

07-038

quantity :

200 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 1

Reference
Clarke T, Sanchez Bailon M, Chiang K, Reynolds J, Herrero Ruiz J, Bandeiras T, et al. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination. Mol Cell. 2017;65:900-916.e7 pubmed publisher

product information

Catalog Number :

07-038

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Tip60 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q92993

Host Name :

Rabbit

Antigen :

Tip60

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Tip60 Antibody

Cross Reactivity :

Human;Mouse

Background :

Histone acetyltransferase HTATIP (Tip60). Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Direct binding of HTATIP to the TAT protein of the human immunodeficiency virus (HIV) might be an important feature for efficient TAT transactivation of HIV gene expression.

ALT Names :

60 kDa Tat interactive protein;HIV-1 Tat interactive protein;HIV-1 Tat interactive protein, 60kDa;K(lysine) acetyltransferase 5;K-acetyltransferase;Tat interacting protein, 60kDa;cPLA(2)-interacting protein;cPLA2 interacting protein;Histone acetyltransferase KAT5;KAT5

Immunogen :

KLH-conjugated, synthetic peptide corresponding to amino acids 494-513 (RIDSKCLHF-TPKDWSKRGKW) of human Tip60.

Specificity :

Recognizes Tip60, Mr 60 kDa. Additional proteins were detected at 66 kDa and 80 kDa in some human and mouse cell lines.

Package Size :

200 µg

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.