NFκB p50 Antibody | EMD Millipore 06-886 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NFκB p50 Antibody

catalog :

06-886

quantity :

150 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, brewer's yeast

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 5a	Wang Y, Yun C, Gao B, Xu Y, Zhang Y, Wang Y, et al. The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. Cell Rep. 2017;20:600-612 pubmed publisher
western blot; brewer's yeast; 1:2500-1:6000; loading ...; fig s1e	Young C, Hillyer C, Hokamp K, Fitzpatrick D, Konstantinov N, Welty J, et al. Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast. BMC Genomics. 2017;18:107 pubmed publisher
western blot; mouse; fig 1	Hunter J, Butterworth J, Zhao B, Sellier H, Campbell K, Thomas H, et al. The NF-ÎºB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma. Oncogene. 2016;35:3476-84 pubmed publisher

product information

Catalog Number :

06-886

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-NFκB p50 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P19838

Host Name :

Rabbit

Antigen :

NFκB p50

Conjugate :

Serum

Isotype :

IgG

Product Description :

Anti-NFκB p50 Antibody

Cross Reactivity :

Human;Mouse

Background :

Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp κB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

ALT Names :

DNA binding factor KBF1;DNA-binding factor KBF1;nuclear factor NF-kappa-B p50 subunit;nuclear factor kappa-B DNA binding subunit;nuclear factor kappa-B, subunit 1;nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Immunogen :

KLH conjugated synthetic peptide (MAEDDPYLGRPE-C) corresponding to amino acids 1-12 of NFκB p50, containing a C-terminal cysteine.

Specificity :

Recognizes NFκB p50, MW 50 kDa and its 105 kDa precursor.

Package Size :

150 µL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at from date of receipt.