GABAA Receptor α1 Antibody | EMD Millipore 06-868 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GABAA Receptor α1 Antibody

catalog :

06-868

quantity :

200 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig e2c	Laverty D, Desai R, Uchański T, Masiulis S, Stec W, Malinauskas T, et al. Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. Nature. 2019;565:516-520 pubmed publisher
immunohistochemistry; mouse; loading ...; fig 4a	Martenson J, Yamasaki T, Chaudhury N, Albrecht D, Tomita S. Assembly rules for GABAA receptor complexes in the brain. elife. 2017;6: pubmed publisher
western blot; mouse; fig 2h	Chen M, Wang J, Jiang J, Zheng X, Justice N, Wang K, et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. elife. 2017;6: pubmed publisher
immunocytochemistry; rat; 1:1000; loading ...; fig 1e western blot; rat; 1:1000; loading ...; fig 1d	Gross G, Straub C, Perez Sanchez J, Dempsey W, Junge J, Roberts R, et al. An E3-ligase-based method for ablating inhibitory synapses. Nat Methods. 2016;13:673-8 pubmed publisher

product information

Catalog Number :

06-868

Subcategory :

Neuroscience

Product Name :

Anti-GABAA Receptor α1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P62813

Host Name :

Rabbit

Antigen :

GABAA Receptor α1

Conjugate :

Affinity Purified

Product Description :

Anti-GABAA Receptor α1 Antibody

Cross Reactivity :

Rat;Mouse

Background :

The neurotransmitter GABA (gamma-aminobutyric acid) binds to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neurons. Three general classes of GABA receptors are known: GABAA and GABAC (ionotropic) receptors and GABAB (metabotropic) receptors. The GABAA (gamma-Aminobutyric Acid type A) receptor is a multiprotein complex that acts as a ligand-gated chloride channel. These receptors are hetero-oligomers, for which 6 subunits are currently known (a, b, g, d, e and r). There are at least 6 different isoforms of the alpha subunit, and receptor subunit expression varies during development. Increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses is responsible for the fast inhibitory synaptic currents observed during postnatal development. Additionally, alpha1-containing GABAA receptors are important in regulating the reinforcing properties of alcohol, and expression of the alpha1 subunit increases upon chronic exposure to alcohol, making it a potential therapeutic target for alcohol dependency.

ALT Names :

Gamma-Amino Butyric Acid Receptor Subunit Alpha-1;Gaba(A) Receptor Subunit Alpha-1;GABA(A) receptor subunit alpha-1;gamma-aminobutyric acid (GABA) A receptor, alpha 1;gamma-aminobutyric acid A receptor, alpha 1

Immunogen :

KLH-conjugated linear peptide corresponding to the topological domain of rat GABAA Receptor α1.

Specificity :

This antibody recognizes the topographical domain of GABAA Receptor α1.

Package Size :

200 µL

Uses :

Western Blotting;Immunohistochemistry (Paraffin);Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt