CREB Antibody | EMD Millipore 06-863 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CREB Antibody

catalog :

06-863

quantity :

200 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 5a western blot; human; loading ...; fig 4a	Bu Q, Wang A, Hamzah H, Waldman A, Jiang K, Dong Q, et al. CREB Signaling Is Involved in Rett Syndrome Pathogenesis. J Neurosci. 2017;37:3671-3685 pubmed publisher
	Mishra R, Benlhabib H, Guo W, Lerma Cervantes C, Mendelson C. Developmental Decline in the MicroRNA 199a (miR-199a)/miR-214 Cluster in Human Fetal Lung Promotes Type II Cell Differentiation by Upregulating Key Transcription Factors. Mol Cell Biol. 2018;38: pubmed publisher
	Chen Z, Lin S, Li J, Ni W, Guo R, Lu J, et al. CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells. Oncogene. 2018;37:1885-1895 pubmed publisher
	Pahng A, Paulsen R, McGinn M, Edwards K, Edwards S. Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats. Neuroscience. 2017;366:1-14 pubmed publisher
	Naranjo J, Zhang H, Villar D, GonzÃ¡lez P, Dopazo X, MorÃ³n Oset J, et al. Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. J Clin Invest. 2016;126:627-38 pubmed publisher

product information

Catalog Number :

06-863

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-CREB Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P16220

Host Name :

Rabbit

Antigen :

CREB

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-CREB Antibody

Cross Reactivity :

Human;Mouse

Background :

CREB is a β-ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2.

ALT Names :

active transcription factor CREB;cAMP responsive element binding protein 1;cAMP-response element-binding protein-1;transactivator protein

Immunogen :

KLH-conjugated, synthetic peptide (CSGAENQ QSGDAAVTEAENQQ) corresponding to a.a. 5-24 of human CREB. The immunizing sequence is identical in pig, shares 19 of 20 residues with mouse and bovine and 18 of 20 residues with rat.

Specificity :

This antibody recognizes CREB.

Package Size :

200 µg

Uses :

Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing cap.