phospho-PKCepsilon (Ser729) | EMD Millipore 06-821 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-PKCepsilon (Ser729)

catalog :

06-821

quantity :

200 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot

product information

Catalog Number :

06-821

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-PKCepsilon (Ser729)

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

NM_005400

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-phospho-PKCepsilon (Ser729)

Cross Reactivity :

Human, Mouse, Rat, Rabbit

Background :

Protein Kinase C epsilon (PKC epsilon) is an ~87 kDa (migrates predominantly as 95 kDa in quiescient cells) member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival, metastasis and transcriptional regulation. PKC epsilon is an actin cytoskeleton regulating protein whose overexpression confers an oncogenic phenotype by affecting the ras signaling cascade. PKC epsilon is phosphorylated by PDK1 on threonine 566 and is then autophosphorylated on the turn motif threonine 710 and the hydrophobic motif serine 729. Catalytically inactive PKC epsilon is not phosphorylated on serine 729. Phosphorylation of serine 729 is mediated by mTOR-dependent pathways, plays an important role in regulating PKC epsilon subcellular localization, and is responsible for the appearance of the 92 kDa PKC epsilon species.

ALT Names :

protein kinase C, epsilon

Immunogen :

KLH conjugated synthetic peptide corresponding to amino acids 726-735 (CKGF[pS]YFGEDL) of human PKCepsilon. The sequence is identical in mouse, rat and rabbit.

Specificity :

Recognizes PKCepsilon phosphorylated on serine residue 729.

Purity :

Protein A purfied

Package Size :

200 ug

Uses :

Storage :

Stable for 1 year at from date of receipt.