phospho-PKCepsilon Antibody (Ser729) | EMD Millipore 06-821-I product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-PKCepsilon Antibody (Ser729)

catalog :

06-821-I

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog Number :

06-821-I

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-PKCepsilon Antibody (Ser729)

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q02156

Host Name :

Rabbit

Antigen :

phospho-PKCepsilon (Ser729)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-PKCepsilon Antibody (Ser729)

Cross Reactivity :

Human;Rat;Mouse

Background :

Protein Kinase C epsilon (PKC epsilon) is an ~87 kDa (migrates predominantly as 95 kDa in quiescient cells) member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival, metastasis and transcriptional regulation. PKC epsilon is an actin cytoskeleton regulating protein whose overexpression confers an oncogenic phenotype by affecting the ras signaling cascade. PKC epsilon is phosphorylated by PDK1 on threonine 566 and is then autophosphorylated on the turn motif threonine 710 and the hydrophobic motif serine 729. Catalytically inactive PKC epsilon is not phosphorylated on serine 729. Phosphorylation of serine 729 is mediated by mTOR-dependent pathways, plays an important role in regulating PKC epsilon subcellular localization, and is responsible for the appearance of the 92 kDa PKC epsilon species.

ALT Names :

PKCepsilon;PKCe;Protein kinase C epsilon type;nPKC-epsilon

Immunogen :

KLH-conjugated linear peptide corresponding to human PKC phosphorylated at Ser729.

Specificity :

This antibody demonstrates cross-reactivity against the PKCbeta (Ser661) isoform, PKCdelta (Ser655) isoform, and possibly PKCalpha (Ser729), all of which contain the GF(pS)Y motif.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt