FcεRI Antibody, γ subunit | EMD Millipore 06-727 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

FcεRI Antibody, γ subunit

catalog :

06-727

quantity :

200 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; 1:300; loading ...; fig 1c	Honjoh C, Chihara K, Yoshiki H, Yamauchi S, Takeuchi K, Kato Y, et al. Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk. Sci Rep. 2017;7:46064 pubmed publisher
western blot; human; loading ...; fig 3a	Battram A, Durrant T, Agbani E, Heesom K, Paul D, Piatt R, et al. The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling. J Biol Chem. 2017;292:1691-1704 pubmed publisher

product information

Catalog Number :

06-727

Subcategory :

Inflammation & Immunology

Product Name :

Anti-FcεRI Antibody, γ subunit

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P30273

Host Name :

Rabbit

Antigen :

FcεRI

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-FcεRI Antibody, γ subunit

Cross Reactivity :

Human;Mouse;Rat

Background :

Type I allergic reactions are mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for type I allergic reactions. The FceRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.

ALT Names :

Fc fragment of IgE, high affinity I, receptor for, gamma polypeptide;Fc fragment of IgE, high affinity I, receptor for;gamma polypeptide;Fc-epsilon RI-gamma;FceRI gamma;IgE Fc receptor subunit gamma;immunoglobulin E receptor, high affinity, gamma chain

Immunogen :

Synthetic peptide KHEKPPQ corresponding to amino acids 80-86 of γ-subunit of Fc receptors.

Specificity :

Recognizes and is specific for FcεRI, γ-subunit, MW 10kDa.

Package Size :

200 μg

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at from date of receipt.