mGluR2/3 Antibody 06-676 | EMD Millipore 06-676 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

mGluR2/3 Antibody 06-676

catalog :

06-676

quantity :

200 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig s12c	Carlyle B, Kitchen R, Kanyo J, Voss E, Pletikos M, Sousa A, et al. A multiregional proteomic survey of the postnatal human brain. Nat Neurosci. 2017;20:1787-1795 pubmed publisher
	Hernandez C, McQuail J, Schwabe M, Burke S, Setlow B, Bizon J. Age-Related Declines in Prefrontal Cortical Expression of Metabotropic Glutamate Receptors that Support Working Memory. Eneuro. 2018;5: pubmed publisher
	Ritter Makinson S, Paquet M, Bogenpohl J, Rodin R, Chris Yun C, Weinman E, et al. Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Neuroscience. 2017;353:58-75 pubmed publisher
	Szoboszlay M, LÅ‘rincz A, Lanore F, Vervaeke K, Silver R, Nusser Z. Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells. Neuron. 2016;90:1043-56 pubmed publisher

product information

Catalog Number :

06-676

Subcategory :

Neuroscience

Product Name :

Anti-mGluR2/3 Antibody 06-676

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q14416

Host Name :

Rabbit

Antigen :

mGluR2/3 06-676

Conjugate :

Affinity Purified

Product Description :

Anti-mGluR2/3 Antibody 06-676

Cross Reactivity :

Human;Rat

Background :

Two very important glutamate receptors in the brain are the metabotropic glutamate receptors, mGLUR2 and mGLUR3. mGLUR2 and mGLUR3 work to inhibit adenylate cyclase activity because they operate through the Gi/Go inhibitory G-proteins. Thus they decrease NMDA receptor activity and mediate excitotoxicity and are often targets to attenuate schizophrenia and hyper-excitability brain activity. mGLUR2 and mGLUR3 are primarily localized on presynaptic membranes. They are members of what is termed Group II glutamate receptors and work to reduce the activity of postsynaptic potentials both excitatory and inhibitory in the cortex. Because of their mediating effects synaptic signals, mGLUR2/3 receptors have emerged as exciting targets for novel therapeutic agents used in treating psychiatric disorders. Moreover recent research shows that glutamate receptors can form natural hybrid receptors with other receptors like those for serotonin, and that these heterocomplex formations could be part of the pathophysiology of such brain disorders as schizophrenia.

ALT Names :

mGluR2;mGluR3

Immunogen :

KLH-conjugated linear peptide corresponding to the C-terminus of human mGluR2.

Specificity :

mGluR2 and mGluR3

Package Size :

200 μg

Uses :

Western Blotting;Immunoprecipitation;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.