This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
acetyl-Histone H3 Antibody
catalog :
06-599
quantity :
100 μg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
great pond snail, human, mouse, rat, brewer's yeast
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, ChIP-Seq, other
citations: 110
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 7b
Lamaa A, Humbert J, Aguirrebengoa M, Cheng X, Nicolas E, Cote J, et al. Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation. elife. 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Qiu J, Villa M, Sanin D, Buck M, O Sullivan D, Ching R, et al. Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Rep. 2019;27:2063-2074.e5 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 1d
Song K, Kim J, Lee Y, Bae H, Lee H, Woo S, et al. Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance. J Clin Invest. 2018;128:4098-4114 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 5d
Qin L, Ma K, Wang Z, Hu Z, Matas E, Wei J, et al. Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nat Neurosci. 2018;21:564-575 pubmed publisher
  • chromatin immunoprecipitation; mouse; 1:20,000; loading ...; fig 4h
Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, et al. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death Differ. 2018;25:1625-1637 pubmed publisher
  • chromatin immunoprecipitation; mouse; 1:500; loading ...; fig 7g
Meng Z, Tao W, Sun J, Wang Q, Mi L, Lin J. Uncoupling Exercise Bioenergetics From Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle. Diabetes. 2018;67:85-97 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 1c
Getz A, Xu F, Visser F, Persson R, Syed N. Tumor suppressor menin is required for subunit-specific nAChR α5 transcription and nAChR-dependent presynaptic facilitation in cultured mouse hippocampal neurons. Sci Rep. 2017;7:1768 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s3b
Coni S, Mancuso A, Di Magno L, Sdruscia G, Manni S, Serrao S, et al. Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. Sci Rep. 2017;7:44079 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 6e
Chang Y, Lin T, Campbell M, Pan C, Lee S, Lee H, et al. REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer. Sci Rep. 2017;7:42795 pubmed publisher
  • chromatin immunoprecipitation; rat; loading ...; tbl 1
Kumar A, Dumasia K, Deshpande S, Balasinor N. Direct regulation of genes involved in sperm release by estrogen and androgen through their receptors and coregulators. J Steroid Biochem Mol Biol. 2017;171:66-74 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...
Altieri F, Di Stadio C, Federico A, Miselli G, De Palma M, Rippa E, et al. Epigenetic alterations of gastrokine 1 gene expression in gastric cancer. Oncotarget. 2017;8:16899-16911 pubmed publisher
  • western blot; brewer's yeast; 1:5000; loading ...; fig s1e
Young C, Hillyer C, Hokamp K, Fitzpatrick D, Konstantinov N, Welty J, et al. Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast. BMC Genomics. 2017;18:107 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 6b
Lin Y, Lin Y, Huang M, Kuo P, Wu C, Lee M, et al. Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification. Mol Immunol. 2017;83:82-91 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3d
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 5c
Hennika T, Hu G, Olaciregui N, Barton K, Ehteda A, Chitranjan A, et al. Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models. PLoS ONE. 2017;12:e0169485 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5b
  • western blot; mouse; loading ...; fig 5a
Greene T, Tokuyama M, Knudsen G, Kunz M, Lin J, Greninger A, et al. A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression. elife. 2016;5: pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 7f
Bao K, Carr T, Wu J, Barclay W, Jin J, Ciofani M, et al. BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity. J Immunol. 2016;197:4371-4381 pubmed
  • western blot; human; 1:2000; loading ...; fig 1a
Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier J, Ye T, et al. KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification. Nat Commun. 2016;7:13227 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig s4b
Li S, Hu H, He Z, Liang D, Sun R, Lan K. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog. 2016;12:e1005900 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3i
Harrod A, Fulton J, Nguyen V, Periyasamy M, Ramos Garcia L, Lai C, et al. Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene. 2017;36:2286-2296 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4f
Patrick N, Griggs C, Icenogle A, Gilpatrick M, Kadiyala V, Jaime Frias R, et al. Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1. J Steroid Biochem Mol Biol. 2017;167:1-13 pubmed publisher
  • chromatin immunoprecipitation; brewer's yeast; fig 2
Abraham K, Chan J, Salvi J, Ho B, Hall A, Vidya E, et al. Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids. Nucleic Acids Res. 2016;44:8870-8884 pubmed
  • western blot; human; 1:1000; fig s09
Oudejans C, Poutsma A, Michel O, Thulluru H, Mulders J, van de Vrugt H, et al. Noncoding RNA-regulated gain-of-function of STOX2 in Finnish pre-eclamptic families. Sci Rep. 2016;6:32129 pubmed publisher
  • western blot; great pond snail; 1:2000; fig 2
Getz A, Visser F, Bell E, Xu F, Flynn N, Zaidi W, et al. Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons. Sci Rep. 2016;6:31779 pubmed publisher
  • chromatin immunoprecipitation; human; fig 6
Kang M, Park K, Yang J, Lee C, Oh S, Yun J, et al. miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells. PLoS ONE. 2016;11:e0160961 pubmed publisher
  • western blot; human; fig 4a
Ramakrishnan S, Ku S, Ciamporcero E, Miles K, Attwood K, Chintala S, et al. HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma. BMC Cancer. 2016;16:617 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 4f
Rada M, Vasileva E, Lezina L, Marouco D, Antonov A, Macip S, et al. Human EHMT2/G9a activates p53 through methylation-independent mechanism. Oncogene. 2017;36:922-932 pubmed publisher
  • western blot; human; 1:1000; fig 5e,7b
Grinshtein N, Rioseco C, Marcellus R, UEHLING D, Aman A, Lun X, et al. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Oncotarget. 2016;7:59360-59376 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3a
  • chromatin immunoprecipitation; mouse; loading ...; fig 3a
  • western blot; mouse; loading ...; fig 3c
Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
  • western blot; human; 1:500; fig 5
Kurg R, Reinsalu O, Jagur S, Ounap K, Võsa L, Kasvandik S, et al. Biochemical and proteomic characterization of retrovirus Gag based microparticles carrying melanoma antigens. Sci Rep. 2016;6:29425 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig st3
Gwak J, Shin J, Lee K, Hong S, Oh S, Goh S, et al. SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells. Oncotarget. 2016;7:48250-48264 pubmed publisher
  • chromatin immunoprecipitation; human; fig 2
Chen D, Kluz T, Fang L, Zhang X, Sun H, Jin C, et al. Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1. PLoS ONE. 2016;11:e0157317 pubmed publisher
  • western blot; human; fig 2
Lin S, Wang B, Lin C, Chien P, Wu Y, Ko J, et al. Chidamide alleviates TGF-?-induced epithelial-mesenchymal transition in lung cancer cell lines. Mol Biol Rep. 2016;43:687-95 pubmed publisher
  • chromatin immunoprecipitation; human; fig 4
Alarcón V, Hernández S, Rubio L, Alvarez F, Flores Y, Varas Godoy M, et al. The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state. Sci Rep. 2016;6:25901 pubmed publisher
  • western blot; human; loading ...; fig 1f
Devaiah B, Case Borden C, Gegonne A, Hsu C, Chen Q, Meerzaman D, et al. BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin. Nat Struct Mol Biol. 2016;23:540-8 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 3
Douvaras P, Rusielewicz T, Kim K, Haines J, CASACCIA P, Fossati V. Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes. Int J Mol Sci. 2016;17: pubmed publisher
  • immunoprecipitation; mouse; fig 8
Lee B, Lee S, Agulnick A, Lee J, Lee S. Single-stranded DNA binding proteins are required for LIM complexes to induce transcriptionally active chromatin and specify spinal neuronal identities. Development. 2016;143:1721-31 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 7
Gomez Rodriguez J, Meylan F, Handon R, Hayes E, Anderson S, Kirby M, et al. Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4. Nat Commun. 2016;7:10857 pubmed publisher
  • western blot; mouse; 1:2000; fig 1c
Waldeck K, Cullinane C, Ardley K, Shortt J, Martin B, Tothill R, et al. Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model. Int J Cancer. 2016;139:194-204 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 7
Hwang S, Jang S, Kim M, Kim L, Kim B, Kim H, et al. YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. Nat Commun. 2016;7:10789 pubmed publisher
  • chromatin immunoprecipitation; rat; fig 6
  • western blot; rat; 1:1000; fig 2
Wei J, Xiong Z, Lee J, Cheng J, Duffney L, Matas E, et al. Histone Modification of Nedd4 Ubiquitin Ligase Controls the Loss of AMPA Receptors and Cognitive Impairment Induced by Repeated Stress. J Neurosci. 2016;36:2119-30 pubmed publisher
  • chromatin immunoprecipitation; brewer's yeast; fig 5
  • western blot; brewer's yeast; fig 5
Jones J, Singh P, Govind C. Recruitment of Saccharomyces cerevisiae Cmr1/Ydl156w to Coding Regions Promotes Transcription Genome Wide. PLoS ONE. 2016;11:e0148897 pubmed publisher
  • western blot; mouse; fig s5
Zhang Q, Dan J, Wang H, Guo R, Mao J, Fu H, et al. Tcstv1 and Tcstv3 elongate telomeres of mouse ES cells. Sci Rep. 2016;6:19852 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • chromatin immunoprecipitation; human; fig 3
M L, P P, T K, M P, E S, J P, et al. Essential role of HDAC6 in the regulation of PD-L1 in melanoma. Mol Oncol. 2016;10:735-750 pubmed publisher
  • ChIP-Seq; mouse; tbl  s3
Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, et al. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). PLoS Pathog. 2016;12:e1005372 pubmed publisher
  • chromatin immunoprecipitation; human; fig s4
Terranova Barberio M, Roca M, Zotti A, Leone A, Bruzzese F, Vitagliano C, et al. Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression. Oncotarget. 2016;7:7715-31 pubmed publisher
  • chromatin immunoprecipitation; human; fig 2
Martínez Iglesias O, Alonso Merino E, Gómez Rey S, Velasco Martín J, Martín Orozco R, Luengo E, et al. Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis. Proc Natl Acad Sci U S A. 2016;113:E328-37 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig s2
De Luca T, Pelosi A, Trisciuoglio D, D Aguanno S, Desideri M, Farini V, et al. miR-211 and MITF modulation by Bcl-2 protein in melanoma cells. Mol Carcinog. 2016;55:2304-2312 pubmed publisher
  • chromatin immunoprecipitation; human; fig 1e
Petroni M, Sardina F, Heil C, Sahún Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed publisher
Palomer X, Román Azcona M, Pizarro Delgado J, Planavila A, Villarroya F, Valenzuela Alcaraz B, et al. SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. Signal Transduct Target Ther. 2020;5:14 pubmed publisher
Fan L, Xu S, Zhang F, Cui X, Fazli L, Gleave M, et al. Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells. Cell Death Dis. 2020;11:214 pubmed publisher
Vetreno R, Bohnsack J, Kusumo H, Liu W, Pandey S, Crews F. Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise. Addict Biol. 2020;25:e12731 pubmed publisher
Crochemore C, Fernandez Molina C, Montagne B, Salles A, Ricchetti M. CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Nat Commun. 2019;10:5576 pubmed publisher
Noce V, Battistelli C, Cozzolino A, Consalvi V, Cicchini C, Strippoli R, et al. YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation. Cell Death Dis. 2019;10:768 pubmed publisher
Liu Y, Bao C, Wang L, Han R, Beier U, Akimova T, et al. Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells. Cancers (Basel). 2019;11: pubmed publisher
Johansson J, Nászai M, Hodder M, Pickering K, Miller B, Ridgway R, et al. RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Cell Stem Cell. 2019;24:592-607.e7 pubmed publisher
Cui S, Li L, Yu R, Downes M, Evans R, Hulin J, et al. β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin. Development. 2019;146: pubmed publisher
Saeed U, Kim J, Piracha Z, Kwon H, Jung J, Chwae Y, et al. Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner. J Virol. 2019;93: pubmed publisher
Naik A, Byrd A, Lucander A, Krangel M. Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes. J Exp Med. 2019;216:231-243 pubmed publisher
Kumar M, Kasti K, Balakrishnan L, Milavetz B. Directed Nucleosome Sliding during the Formation of the Simian Virus 40 Particle Exposes DNA Sequences Required for Early Transcription. J Virol. 2019;93: pubmed publisher
Bahat A, Goldman A, Zaltsman Y, Khan D, Halperin C, Amzallag E, et al. MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells. Nat Commun. 2018;9:5132 pubmed publisher
Yang C, Shen W, Chen H, Chu L, Xu Y, Zhou X, et al. Characterization and subcellular localization of histone deacetylases and their roles in response to abiotic stresses in soybean. BMC Plant Biol. 2018;18:226 pubmed publisher
Jin H, Choi S, Kang M, Yun S, Kwon D, Noh Y, et al. Salicylic acid-induced transcriptional reprogramming by the HAC-NPR1-TGA histone acetyltransferase complex in Arabidopsis. Nucleic Acids Res. 2018;46:11712-11725 pubmed publisher
Vandenbon A, Kumagai Y, Lin M, Suzuki Y, Nakai K. Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation. Genome Biol. 2018;19:138 pubmed publisher
Pane L, Fulcoli F, Cirino A, Altomonte A, Ferrentino R, Bilio M, et al. Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer. Dis Model Mech. 2018;11: pubmed publisher
de Bruyn Kops A, Burke J, Guthrie C. Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope. Mol Biol Cell. 2018;29:2578-2590 pubmed publisher
Hung F, Chen F, Li C, Chen C, Lai Y, Chen J, et al. The Arabidopsis LDL1/2-HDA6 histone modification complex is functionally associated with CCA1/LHY in regulation of circadian clock genes. Nucleic Acids Res. 2018;46:10669-10681 pubmed publisher
Umeda M, Tsunekawa C, Senmatsu S, Asada R, Abe T, Ohta K, et al. Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression. Mol Cell Biol. 2018;38: pubmed publisher
Seeley J, Baker R, Mohamed G, Bruns T, Hayden M, Deshmukh S, et al. Induction of innate immune memory via microRNA targeting of chromatin remodelling factors. Nature. 2018;559:114-119 pubmed publisher
Wang B, Yang X, Wang Y, Xie Y, Zhou X. Tomato Yellow Leaf Curl Virus V2 Interacts with Host Histone Deacetylase 6 To Suppress Methylation-Mediated Transcriptional Gene Silencing in Plants. J Virol. 2018;92: pubmed publisher
Tanaka S, Jiang Y, Martinez G, Tanaka K, Yan X, Kurosaki T, et al. Trim33 mediates the proinflammatory function of Th17 cells. J Exp Med. 2018;215:1853-1868 pubmed publisher
Ruiz L, Gurlo T, Ravier M, Wojtusciszyn A, Mathieu J, Brown M, et al. Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. Cell Death Dis. 2018;9:600 pubmed publisher
Cai S, Song Y, Chen C, Shi J, Gan L. Natural chromatin is heterogeneous and self-associates in vitro. Mol Biol Cell. 2018;29:1652-1663 pubmed publisher
Varshney D, Lombardi O, Schweikert G, Dunn S, Suska O, Cowling V. mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription. Cell Rep. 2018;23:1530-1542 pubmed publisher
Zhang J, He Z, Sen S, Wang F, Zhang Q, Sun Z. TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner. J Immunol. 2018;200:3397-3406 pubmed publisher
Pasini A, Brand O, Jenkins G, Knox A, Pang L. Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation. Biochim Biophys Acta Gene Regul Mech. 2018;1861:463-472 pubmed publisher
Wang S, Ko S, Kim Y, Jo S, Lee S, Jung S, et al. Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice. Exp Mol Med. 2018;50:e455 pubmed publisher
Jing H, Su X, Gao B, Shuai Y, Chen J, Deng Z, et al. Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis. Cell Death Dis. 2018;9:176 pubmed publisher
Griggs C, Malm S, Jaime Frias R, Smith C. Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors. Toxicol Appl Pharmacol. 2018;339:110-120 pubmed publisher
Song S, Jeon M, Nam J, Kang J, Lee Y, Kang J, et al. Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer. Oncogene. 2018;37:993-1004 pubmed publisher
Kirschner K, Sciesielski L, Krueger K, Scholz H. Wilms tumor protein-dependent transcription of VEGF receptor 2 and hypoxia regulate expression of the testis-promoting gene Sox9 in murine embryonic gonads. J Biol Chem. 2017;292:20281-20291 pubmed publisher
Garcia Gomez A, Li T, Kerick M, Català Moll F, Comet N, Rodriguez Ubreva J, et al. TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells. Nucleic Acids Res. 2017;45:10002-10017 pubmed publisher
Cao H, Zhang S, Shan S, Sun C, Li Y, Yu S, et al. Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBPβ during early adipocyte differentiation. J Biol Chem. 2017;292:18973-18987 pubmed publisher
Lyu Y, Nakano K, Davis R, Tepper C, Campbell M, Izumiya Y. ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation. J Virol. 2017;91: pubmed publisher
Bohnsack J, Patel V, Morrow A. Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons. J Pharmacol Exp Ther. 2017;363:1-11 pubmed publisher
Green A, Zhan L, Eid A, Zarbl H, Guo G, Richardson J. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. 2017;125:189-196 pubmed publisher
Kishore A, Liang H, Kanchwala M, Xing C, Ganesh T, Akgul Y, et al. Prostaglandin dehydrogenase is a target for successful induction of cervical ripening. Proc Natl Acad Sci U S A. 2017;114:E6427-E6436 pubmed publisher
Dong Y, Isono K, Ohbo K, Endo T, Ohara O, Maekawa M, et al. EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice. Mol Cell Biol. 2017;37: pubmed publisher
Yan L, Wang Y, Liu J, Nie Y, Zhong X, Kan Q, et al. Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin. Mol Pharmacol. 2017;92:113-123 pubmed publisher
Ma H, Fu R, Xu J, Liu Y. A simple and cost-effective setup for super-resolution localization microscopy. Sci Rep. 2017;7:1542 pubmed publisher
Byun S, Kim Y, Zhang Y, Kong B, Guo G, Sadoshima J, et al. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36:1755-1769 pubmed publisher
Gu D, Chen C, Zhao M, Zhao L, Duan X, Duan J, et al. Identification of HDA15-PIF1 as a key repression module directing the transcriptional network of seed germination in the dark. Nucleic Acids Res. 2017;45:7137-7150 pubmed publisher
Shimamoto Y, Tamura S, Masumoto H, Maeshima K. Nucleosome-nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity. Mol Biol Cell. 2017;28:1580-1589 pubmed publisher
Kim H, Jeong Y, Song I, Noh Y, Seo K, Kim M, et al. Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver. Sci Rep. 2017;7:43296 pubmed publisher
Zhu J, Wang J, Chen X, Tsompana M, Gaile D, Buck M, et al. A time-series analysis of altered histone H3 acetylation and gene expression during the course of MMAIII-induced malignant transformation of urinary bladder cells. Carcinogenesis. 2017;38:378-390 pubmed publisher
Dudakovic A, Gluscevic M, Paradise C, Dudakovic H, Khani F, Thaler R, et al. Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing. Gene. 2017;609:28-37 pubmed publisher
Patanun O, Ueda M, Itouga M, Kato Y, Utsumi Y, Matsui A, et al. The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Alleviates Salinity Stress in Cassava. Front Plant Sci. 2016;7:2039 pubmed publisher
Sun R, Tan X, Wang X, Wang X, Yang L, Robertson E, et al. Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues. PLoS Pathog. 2017;13:e1006167 pubmed publisher
Bulusu V, Tumanov S, Michalopoulou E, van den Broek N, Mackay G, Nixon C, et al. Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation. Cell Rep. 2017;18:647-658 pubmed publisher
Sunami Y, Araki M, Kan S, Ito A, Hironaka Y, Imai M, et al. Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017;292:2815-2829 pubmed publisher
Ciarlo E, Heinonen T, Herderschee J, Fenwick C, Mombelli M, Le Roy D, et al. Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo. Sci Rep. 2016;6:37944 pubmed publisher
Yu L, Liang Y, Cao X, Wang X, Gao H, Lin S, et al. Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer. Oncogene. 2017;36:2910-2918 pubmed publisher
Noguera N, Piredda M, Taulli R, Catalano G, Angelini G, Gaur G, et al. PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity. Oncotarget. 2016;7:66386-66397 pubmed publisher
Lake R, Boetefuer E, Won K, Fan H. The CSB chromatin remodeler and CTCF architectural protein cooperate in response to oxidative stress. Nucleic Acids Res. 2016;44:2125-35 pubmed publisher
Bastianelli D, Siciliano C, Puca R, Coccia A, Murdoch C, Bordin A, et al. Influence of Egr-1 in cardiac tissue-derived mesenchymal stem cells in response to glucose variations. Biomed Res Int. 2014;2014:254793 pubmed publisher
Palmisano I, Della Chiara G, D Ambrosio R, Huichalaf C, Brambilla P, Corbetta S, et al. Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4). Proc Natl Acad Sci U S A. 2012;109:E2284-93 pubmed publisher
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product information
Catalog Number :
06-599
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-acetyl-Histone H3 Antibody
Product Type :
Antibodies
Clonality :
Polyclonal Antibody
Gene ID :
Q16695
Host Name :
Rabbit
Antigen :
acetyl-Histone H3
Conjugate :
Purified
Product Description :
Anti-acetyl-Histone H3 Antibody
Cross Reactivity :
Human;Mouse;Rat
Background :
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Acetylation of histone H3 occurs at several different lysine positions in the histone tail and is performed by a family of enzymes known as Histone Acetyl Transferases (HATs). Acetylation of lysine14 is commonly seen in genes that are being actively transcribed into RNA.
ALT Names :
H3 histone family, member T;histone 3, H3;histone cluster 3, H3
Immunogen :
Linear peptide corresponding to human Histone H3 acetylated at the N-terminus.
Specificity :
Recognizes Histone H3 acetylated at the N-terminus.
Package Size :
100 μg
Uses :
Western Blotting;Immunocytochemistry;ChIP-seq;Chromatin Immunoprecipitation (ChIP)
Storage :
Stable for 1 year at 2-8°C from date of receipt
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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