Caspase 1 Antibody | EMD Millipore 06-503-I product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase 1 Antibody

catalog :

06-503-I

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; fig 2	Wang X, Shaw D, Hammond H, Sutterwala F, Rayamajhi M, Shirey K, et al. The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog. 2016;12:e1005803 pubmed publisher
western blot; mouse; loading ...; fig 4a	Smalley C, Bechelli J, Rockx Brouwer D, Saito T, Azar S, Ismail N, et al. Rickettsia australis Activates Inflammasome in Human and Murine Macrophages. PLoS ONE. 2016;11:e0157231 pubmed publisher
	Chen Y, Yin M, Cao X, Hu G, Xiao M. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain. Aging Dis. 2018;9:374-390 pubmed publisher

product information

Catalog Number :

06-503-I

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase 1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P29466

Host Name :

Rabbit

Antigen :

Caspase 1

Conjugate :

Affinity Purified

Product Description :

Anti-Caspase 1 Antibody

Cross Reactivity :

Human

Background :

Caspase-1, also known as IL-1 beta-converting enzyme (ICE), is an enzyme that cleaves the inflammatory cytokines IL-1 beta and IL-18, releasing the mature, active peptides. Caspase-1 is important for defense against pathogens and it also is involved in the induction of apoptosis. Thymocytes from caspase-1 deficient mice are resistant to Fas-mediated apoptosis, and caspase-1 is similar to the cell death gene CED-3 of C. elegans. Caspase-1 is a heterotetramer that consists of two anti-parallel heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The enzyme has a preferred cleavage site of Tyr-Val-Ala-Asp (YVAD). Caspase-1 is highly expressed in spleen and lung, and is absent from brain.

ALT Names :

Caspase-1;CASP-1;Interleukin-1 beta convertase;IL-1BC;Interleukin-1 beta-converting enzyme;ICE;IL-1 beta-converting enzyme;p45

Immunogen :

KLH-conjugated linear peptide corresponding to the p20 subunit of human Caspase 1.

Specificity :

This antibody recognizes the p20 subunit of Caspase 1. This antibody may cross-react with Caspase 5 due to 92% sequence homology. Additionally, this antibody recognizes the P45 proenzyme (~45 kDa) and the p20 subunit (~20 kDa) of the reduced, human Caspase 1 isoforms.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt