STAT1 Antibody, CT | EMD Millipore 06-501 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

STAT1 Antibody, CT

catalog :

06-501

quantity :

250 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation, EMSA

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 3c	Baron L, Paatero A, Morel J, Impens F, Guenin Macé L, Saint Auret S, et al. Mycolactone subverts immunity by selectively blocking the Sec61 translocon. J Exp Med. 2016;213:2885-2896 pubmed
western blot; mouse; 1:2000; fig 4	Speer S, Li Z, Buta S, Payelle Brogard B, Qian L, Vigant F, et al. ISG15 deficiency and increased viral resistance in humans but not mice. Nat Commun. 2016;7:11496 pubmed publisher
	Burr M, Sparbier C, Chan K, Chan Y, Kersbergen A, Lam E, et al. An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. Cancer Cell. 2019;36:385-401.e8 pubmed publisher

product information

Catalog Number :

06-501

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-STAT1 Antibody, CT

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P42224

Host Name :

Rabbit

Antigen :

STAT1

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-STAT1 Antibody, CT

Cross Reactivity :

Human;Mouse

Background :

STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. STAT 1, is activated by a number of different ligands, including IFNalpha, IFNgamma, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions.

Immunogen :

GST fusion-protein containing the carboxy terminal 36 amino acids of human STAT1α

Specificity :

Recognizes STAT1.

Package Size :

250 μg

Uses :

Electrophoretic Mobility Shift Assay;Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt