Bax, NT | EMD Millipore 06-499 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Bax, NT

catalog :

06-499

quantity :

200 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 2

Reference
Weyhenmeyer B, Noonan J, WÃ¼rstle M, Lincoln F, Johnston G, Rehm M, et al. Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide. Oncotarget. 2016;7:61295-61311 pubmed publisher
Berens H, Tyler K. The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J Virol. 2011;85:3858-71 pubmed publisher

product information

Catalog Number :

06-499

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Bax, NT

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

NM_138765

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Bax, NT

Cross Reactivity :

Human, Mouse

Species Summary :

Human and mouse.

Background :

BAX (BCL2-associated X protein) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAX protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

ALT Names :

BCL2-associated X protein, apoptosis regulator BAX

Immunogen :

Synthetic Peptide [MDGSGEQPRGGGPTSS EQIMK-C], corresponding to amino acid residues 1-21 of human Bax with a cysteine residue added on the C-terminus for conjugation to KLH.

Specificity :

Bax alpha p20 and beta p23.

Purity :

Protein G chromatography

Package Size :

200 ug

Uses :

IC, IH, IH(P), IP, WB

Storage :

Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.