IκB-α Antibody | EMD Millipore 06-494 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IκB-α Antibody

catalog :

06-494

quantity :

200 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 4	Starokadomskyy P, Gemelli T, Rios J, Xing C, Wang R, Li H, et al. DNA polymerase-? regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016;17:495-504 pubmed publisher

product information

Catalog Number :

06-494

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-IκB-α Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P25963

Host Name :

Rabbit

Antigen :

IκB-α

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-IκB-α Antibody

Cross Reactivity :

Human;Mouse

Background :

The NF-kappaB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkappaB-alpha protein. In response to many different NF-kappaB-inducing agentsincluding T-cell mitogens, proinflammatory cytokines, and viral transactivatorsthe inhibitory IkappaB-alpha is rapidly phosphorylated and degraded. Phosphorylation of IkappaB-alpha at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin and subsequent degradation of IkappaB-alpha. Phosphorylation of IkappaB-alpha at Ser32 and Ser36 is critical for activation of NF-kappaB, which then translocates to the nucleus and induces transcription of genes that protect organism.

Immunogen :

Purified GST-fusion protein containing full length human IκB-α/MAD-3 protein

Specificity :

Recognizes IκB-α.

Package Size :

200 μg

Uses :

Immunoprecipitation;Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.