phospho-Lck (Tyr505) Antibody | EMD Millipore 06-1423 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Lck (Tyr505) Antibody

catalog :

06-1423

quantity :

100 µL

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, cow, zebrafish

application :

western blot

product information

Catalog Number :

06-1423

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-Lck (Tyr505) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P06239

Host Name :

Rabbit

Antigen :

phospho-Lck (Tyr505)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-Lck (Tyr505) Antibody

Cross Reactivity :

Human;Rat;Mouse;Pig;Sheep;Bovine

Background :

Anti-Phospho-Lck (Tyr505) detects endogenous levels of Lck only when phosphorylated at Tyr505. Lck is a member of the Src family of tyrosine kinases and is most commonly found in T cells. It associates with the cytoplasmic tails of the CD4 on T helper cells and CD8 co-receptors on cytotoxic T cells. The tyrosine phosphorylation cascade initiated by Lck leads to the intracellular mobilization of a calcium (Ca2+) ions and activation of important signaling cascades within the lymphocyte including the Ras-MEK-ERK pathway, which goes on to activate certain transcription factors such as NFAT, NF-κB, and AP-1. These transcription factors regulate the production of gene products, such as Interleukin-2.

ALT Names :

Tyrosine-protein kinase Lck;Leukocyte C-terminal Src kinase;LSK;Lymphocyte cell-specific protein-tyrosine kinase;Protein YT16;Proto-oncogene Lck;T cell-specific protein-tyrosine kinase;p56-LCK

Immunogen :

KLH-conjugated linear peptide corresponding to human Lck phosphorylated at Tyr505.

Specificity :

This antibody recognizes Lck phosphorylated at Tyr505.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt