CDK5RAP2 Antibody | EMD Millipore 06-1398 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CDK5RAP2 Antibody

catalog :

06-1398

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 2	Muroyama A, Seldin L, Lechler T. Divergent regulation of functionally distinct Î³-tubulin complexes during differentiation. J Cell Biol. 2016;213:679-92 pubmed publisher

product information

Catalog Number :

06-1398

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-CDK5RAP2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q96SN8

Host Name :

Rabbit

Antigen :

CDK5RAP2

Conjugate :

Affinity Purified

Product Description :

Anti-CDK5RAP2 Antibody

Cross Reactivity :

Human

Background :

Also known as Cep215, CDK5RAP2 is involved in a variety of cellular processes. It serves as a potential regulator of CDK5 activity through its interaction with CDK5R1. It acts as a negative regulator of centriole disengagement, which maintains centriole engagement and cohesion. It is involved in the regulation of mitotic spindle orientation. Additionally, this protein mediates spindle checkpoint activation by serving as a transcriptional regulator of the MAD2 and BUBR1 promoter. In conjuction with MAPRE1, CDK5RAP2 promotes microtubule polymerization, bundle formation, and growth at the plus ends. It also plays a role in DNA damage-induced G2 cell cycle checkpoint. CDK5RAP2 is known to be mutated in primary microcephaly, a neuodevelopmental disorder that is characterized by a decrease in brain size.

ALT Names :

CDK5 regulatory subunit-associated protein 2;CDK5 activator-binding protein C48;Centrosome-associated protein 215

Immunogen :

MBP-tagged recombinant protein corresponding to human CDK5RAP2.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt