Cyclin D Antibody | EMD Millipore 06-137 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cyclin D Antibody

catalog :

06-137

quantity :

200 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; mouse; 5 ug/ml; fig 1	Fusté N, Fernández Hernández R, Cemeli T, Mirantes C, Pedraza N, Rafel M, et al. Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin. Nat Commun. 2016;7:11581 pubmed publisher

product information

Catalog Number :

06-137

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Cyclin D Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P24385

Host Name :

Rabbit

Antigen :

Cyclin D

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Cyclin D Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

Progression through G1 phase and transition from G1 to S phase of the cell division cycle is controlled by activation of a distinct series of serine/threonine kinase complexes which comprise of a cyclin regulatory subunit and a cyclin dependent kinase (cdk). D type cyclins are induced earlier than cyclin E in G1 and can form complexes with cdk2,-4,-5, and -6. Cyclin D1 is a nuclear protein during G1 phase and disappears from the nucleus in S-phase. Among the key cell cycle regulators, cyclin D1 has been implicated most strongly as a proto-oncogene in several human tumor types, including breast carcinomas.

Immunogen :

peptide corresponding the 11 C-terminal amino acids. residues 285-295, of human Cyclin D1 (CTPTDVRDVDI)

Specificity :

Recognizes Cyclin D1 and D2; no cross-reactivity with Cyclin A or B.

Package Size :

200 μg

Uses :

Immunocytochemistry;Immunoprecipitation;Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.