acetyl-p53 (Lys320) Antibody | EMD Millipore 06-1283 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

acetyl-p53 (Lys320) Antibody

catalog :

06-1283

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, bovine, chimpanzee

application :

western blot, immunocytochemistry

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 1b	Luff S, Kao C, Papoutsakis E. Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis. PLoS ONE. 2018;13:e0203991 pubmed publisher
western blot; human; 1:1000; loading ...; fig s11c	Li F, Liu J, Bao R, Yan G, Feng X, Xu Y, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9:508 pubmed publisher
	Zheng S, Koh X, Goh H, Rahmat S, Hwang L, Lane D. Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res. 2017;77:4342-4354 pubmed publisher

product information

Catalog Number :

06-1283

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-acetyl-p53 (Lys320) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P04637

Host Name :

Rabbit

Antigen :

acetyl-p53 (Lys320)

Conjugate :

Affinity Purified

Product Description :

Anti-acetyl-p53 (Lys320) Antibody

Cross Reactivity :

Human;Chimpanzee;Bovine

Background :

p53 was discovered in 1979 as a cellular protein associating with the transforming protein of SV40 tumor virus. Since then, many different biochemical functions have been attributed to the 53 kD phosphoprotein. Experimental evidence has suggested that p53 acts as a negative regulator of cell growth in normal cells (Finlay, 1989). Thus, the inactivation or mutation of p53 may be an essential step in the development of malignancy (Lane and Benchmol, 1990). Wild-type p53 levels in normal cells and tissues were found to be very low. Mutant p53 polypeptide, however, is often found to be present at high concentrations in mammalian tumors and tumor cell lines. For example, in an immuno-histochemistry study 40% of human breast cancer showed elevated levels of mutant p53 in the cell nucleus. Mutations of the p53 protein have some characteristic features: a) Most of them are missense point mutations giving rise to an altered protein function. b) Many -but not all- mutant p53 proteins exhibit a common mutant structure, which can be recognized by monoclonal antibodies specific for p53 in the mutant conformation.

ALT Names :

Antigen NY-CO-13;Phosphoprotein p53;Tumor suppressor p53;p53 antigen;p53 transformation suppressor;p53 tumor suppressor;transformation-related protein 53;tumor protein p53

Immunogen :

KLH-conjugated linear peptide corresponding to p53 at Lys320.

Specificity :

This antibody recognizes p53 acetylated at Lys320.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt