Sonic Hedgehog Antibody | EMD Millipore 06-1106 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Sonic Hedgehog Antibody

catalog :

06-1106

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Shackleford G, Shi X, Swanson K, Mahdi M, Gonzalez Gomez I, Asgharzadeh S, et al. BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS ONE. 2016;11:e0156907 pubmed publisher

product information

Catalog Number :

06-1106

Subcategory :

Cell Signaling

Product Name :

Anti-Sonic Hedgehog Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q15465

Host Name :

Rabbit

Antigen :

Sonic Hedgehog

Conjugate :

Affinity Purified

Product Description :

Anti-Sonic Hedgehog Antibody

Cross Reactivity :

Human;Mouse

Background :

Sonic Hedgehog Protein (SHH, VHH-1) belongs to hedgehog protein family which includes Indian Hh, and Desert Hh. Hh family is involved in the cell fate and patterning during embryonic development, homeostasis, and adult tissue renewal. Similar to other member in the family, SHH binds to the patched (PTC) cell surface receptor, releasing the signal transducer Smoothened (Smo) to transmit the Hh signal into the cell and activate transcription of the target gene. Precursor SHH is autocatlytically cleaved into two subunits, N-terminal and C-terminal products. Soluble N-terminal product is involved in the signaling activity, while C-product displays an autoproteolysis activity on the precursor and a cholesterol transferase activity on the N-terminal product. C-terminal product attaches a cholesterol moiety to the N-terminal product, preventing N-terminal product diffusion within the developing embryo. A defect in SHH has been linked in holoprosencephaly type 3 (HPE3), in which developing forebrain fails to separate into right and left hemispheres, and ocular coloboma.

ALT Names :

sonic hedgehog;sonic hedgehog (Drosophila) homolog;sonic hedgehog homolog (Drosophila)

Immunogen :

GST-tagged recombinant protein corresponding to the N-terminus of Sonic HedgeHog.

Specificity :

This antibody recognizes the N-terminus of Sonic Hedgehog.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt