IPS-1 Antibody | EMD Millipore 06-1096 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IPS-1 Antibody

catalog :

06-1096

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

product information

Catalog Number :

06-1096

Subcategory :

Inflammation & Immunology

Product Name :

Anti-IPS-1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q7Z434

Host Name :

Rabbit

Antigen :

IPS-1

Conjugate :

Affinity Purified

Product Description :

Anti-IPS-1 Antibody

Cross Reactivity :

Human

Background :

Interferon-beta promoter stimulator 1 (IPS-1, gene name: MAVS/VISA) is required for innate immune defense against viruses and acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). TBK1 and IKKi protein kinases are required for the IPS-1-mediated interferon induction, although IPS-1 does not directly interact with TBK1. Located in the mitochondrial outer membrane, IPS-1 also interacts with TRAF2 and TRAF6 and may interact with IRF3, FADD, RIPK1, IKBKE, CHUK and IKBKB. In relation to viral response, IPS-1 interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases, as well as HHAV protein 3ABC and NLRX1.

ALT Names :

CARD adapter inducing interferon-beta;CARD adaptor inducing IFN-beta;IFN-B promoter stimulator 1;Interferon-beta promoter stimulator protein 1;Putative NF-kappa-B-activating protein 031N;Virus-induced-signaling adapter;mitochondrial anti-viral signaling protein;mitochondrial antiviral signaling protein;virus-induced signaling adapter;virus-induced signaling adapter variant 1b;virus-induced signaling adaptor variant 1a

Immunogen :

KLH-conjugated linear peptide corresponding to human IPS-1 at and around the cytoplasmic domain.

Specificity :

This antibody recognizes interferon-beta promoter stimulator protein 1 (IPS-1).

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt