TGF-beta Receptor Antibody, type I | EMD Millipore 06-1086 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TGF-beta Receptor Antibody, type I

catalog :

06-1086

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dog, cow

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

06-1086

Subcategory :

Inflammation & Immunology

Product Name :

Anti-TGF-beta Receptor Antibody, type I

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P36897

Host Name :

Rabbit

Antigen :

TGF-beta Receptor

Conjugate :

Affinity Purified

Product Description :

Anti-TGF-beta Receptor Antibody, type I

Cross Reactivity :

Human;Mouse;Horse;Rat;Opossum;Pig;Bovine;Canine

Background :

Transforming growth factor, beta receptor type I (TGF-beta receptor I) forms a heteromeric complex with TGF-beta receptor type II when bound to TGF-beta. This complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta receptor I is found in all tissues, but is most abundant in placenta and least abundant in brain and heart tissue. TGF-beta receptor I is phosphorylated at basal levels in the absence of ligand binding and is multiply phosphorylated, mainly in the GS region. Defects in TGF-beta receptor I are the cause of Loeys-Dietz syndrome type 1A (LDS1A), also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS) (Uniprot/Swissprot).

ALT Names :

TGF-beta receptor type-1;Transforming growth factor-beta receptor type I;TGF-beta receptor type I;TGF-beta type I receptor;Serine/threonine-protein kinase receptor R4;Activin receptor-like kinase 5

Immunogen :

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of TGF-beta receptor, type-I.

Specificity :

Antibody recognizes the cytoplasmic domain of TGF-beta receptor, type-I.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt