Deubiquitinating enzyme A (DUBA) Antibody | EMD Millipore 06-1062 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Deubiquitinating enzyme A (DUBA) Antibody

catalog :

06-1062

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dog, cow, chimpanzee

application :

western blot

product information

Catalog Number :

06-1062

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Deubiquitinating enzyme A (DUBA) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q96G74

Host Name :

Rabbit

Antigen :

Deubiquitinating enzyme A (DUBA)

Conjugate :

Affinity Purified

Product Description :

Anti-Deubiquitinating enzyme A (DUBA) Antibody

Cross Reactivity :

Human;Mouse;Canine;Bovine;Chimpanzee;Rat

Background :

Deubiquitinating enzyme A (DUBA), an ovarian tumor domain-containing deubiquitinating enzyme, is a negative regulator of innate immune system and a regulator of type I interferon production. DUBA's deubiquitinating activity is directed towards 'Lys-63'-linked polyubiquitin chains and can be inhibited by N-ethyl-maleimide (NEM). DUBA binds to tumor necrosis factor receptor–associated factor 3 (TRAF3), an adaptor protein essential for type I interferon response. TRAF3 is an E3 ubiquitin ligase that preferentially assembles lysine-63–linked polyubiquitin chains. DUBA selectively cleaves the lysine-63–linked polyubiquitin chains on TRAF3, resulting in its dissociation from the downstream signaling complex containing TANK-binding kinase 1. (Kayagaki, N., et al., 2007)

ALT Names :

Deubiquinating enzyme A;OTU domain containing 5

Immunogen :

KLH-conjugated linear peptide corresponding to human Deubiquitinating enzyme A (DUBA).

Specificity :

This antibody recognizes Deubiquitinating enzyme A (DUBA).

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt