phospho-Bcl-2 (Ser70) Antibody, clone 69-10C-2-10C-18, rabbit monoclonal | EMD Millipore 05-843R product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Bcl-2 (Ser70) Antibody, clone 69-10C-2-10C-18, rabbit monoclonal

catalog :

05-843R

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

69-10C-2-10C-18

reactivity :

human

application :

western blot, immunoprecipitation, flow cytometry

product information

Catalog Number :

05-843R

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-phospho-Bcl-2 (Ser70) Antibody, clone 69-10C-2-10C-18, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10415

Host Name :

Rabbit

Antigen :

phospho-Bcl-2 (Ser70)

Clone :

69-10C-2-10C-18

Conjugate :

Unconjugated

Isotype :

IgG

Product Description :

Anti-phospho-Bcl-2 (Ser70) Antibody, clone 69-10C-2-10C-18, rabbit monoclonal

Cross Reactivity :

Human

Background :

The Bcl name is derived from B-cell chronic lymphocytic leukemia, and was given to genes involved in that disease. Members of the Bcl-2 family share homologous domains (BH) through which they are able to homo- and hetero-dimerize. Bcl-2 plays an important role in cytochrome c release from the mitochondria; it also binds Apaf1, inhibiting Apaf-1 association with caspase-9. Bcl-2 overexpression in indicated in a number of human cancers, including melanoma, breast, prostate, and lung, and it correlates with resistance to cancer treatment (presumably due to decreased apoptosis). Bcl-2 has also been implicated in schizophrenia and autoimmune disorders. Bcl-2 phosphorylated at Ser-70 plays a critial role in the translocation of Bax from the cytosol to the mitochondria, and this may regulate NO-induced neuronal apoptosis. The molecular mechanism of Bcl-2 phosphorylation and its relationship to Bax is largely unknown.

ALT Names :

B-cell CLL/lymphoma 2;B-cell lymphoma protein 2

Immunogen :

KLH-conjugated linear peptide corresponding to human phosphorylated Bcl-2 at Ser70.

Specificity :

This antibody recognizes phosphorylated Bcl-2 at Ser70.

Package Size :

100 µL

Uses :

Western Blotting;Immunoprecipitation;Flow Cytometry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.