IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1 | EMD Millipore 05-840 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1

catalog :

05-840

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10.1

The same clone is also sold as:

OriGene: TA319542, AM01159PU-N
MilliporeSigma: SAB3701446
LifeSpan Biosciences: LS-C153780
Rockland Immunochemicals: 200-301-E57
Bio-Rad: OBT2037G

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1b	Romani L, Oikonomou V, Moretti S, Iannitti R, D Adamo M, Villella V, et al. Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nat Med. 2017;23:590-600 pubmed publisher
western blot; human; fig 5	Sherchand S, Ibana J, Zea A, Quayle A, Aiyar A. The High-Risk Human Papillomavirus E6 Oncogene Exacerbates the Negative Effect of Tryptophan Starvation on the Development of Chlamydia trachomatis. PLoS ONE. 2016;11:e0163174 pubmed publisher
immunohistochemistry - paraffin section; human; 1:25; fig 2b	Friedman K, Brodsky A, Lu S, Wood S, Gill A, Lombardo K, et al. Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. Mod Pathol. 2016;29:528-41 pubmed publisher
western blot; human; 1:500; fig 2	Miranda A, Funes J, SÃ¡nchez N, Limia C, Mesa M, Quezada S, et al. Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure. Cancer Res. 2015;75:3032-42 pubmed publisher
western blot; human; fig 4	Romani R, Pirisinu I, Calvitti M, Pallotta M, Gargaro M, Bistoni G, et al. Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3-dioxygenase1. J Cell Mol Med. 2015;19:1593-605 pubmed publisher
	Carbotti G, Barisione G, Airoldi I, Mezzanzanica D, Bagnoli M, Ferrero S, et al. IL-27 induces the expression of IDO and PD-L1 in human cancer cells. Oncotarget. 2015;6:43267-80 pubmed publisher
	Laranjeira P, Gomes J, Pedreiro S, Pedrosa M, Martinho A, Antunes B, et al. Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells. Stem Cells Int. 2015;2015:819084 pubmed publisher
	Jacca S, Franceschi V, Agosti M, Cavirani S, Mistretta F, Donofrio G. Interferon gamma-mediated BoHV-4 replication restriction in bovine endometrial stromal cells is host IDO1 gene expression independent and BoHV-4 IE2 gene expression dependent. Biol Reprod. 2014;91:112 pubmed publisher
	Yu J, Sun J, Wang S, Li H, Cao S, Cong Y, et al. Upregulated expression of indoleamine 2, 3-dioxygenase in primary breast cancer correlates with increase of infiltrated regulatory T cells in situ and lymph node metastasis. Clin Dev Immunol. 2011;2011:469135 pubmed publisher
	Niinisalo P, Oksala N, Levula M, Pelto Huikko M, Jarvinen O, Salenius J, et al. Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study. Ann Med. 2010;42:55-63 pubmed publisher

product information

Catalog Number :

05-840

Subcategory :

Inflammation & Immunology

Product Name :

Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P14902

Host Name :

Mouse

Antigen :

IDO (Indoleamine 2

Clone :

10.1

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1

Cross Reactivity :

Human;Mouse

Background :

Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.

ALT Names :

Indoleamine 2,3-dioxygenase;Indoleamine-pyrrole 2,3-dioxygenase;indole 2,3-dioxygenase;indoleamine-pyrrole 2,3 dioxygenase

Immunogen :

GST fusion protein corresponding to residues 78-184 of human Indoleamine 2,3- Dioxygenase (IDO). Clone 10.1.

Specificity :

Recognizes IDO (Indoleamine 2,3- Dioxygenase), Mr 42kDa.

Package Size :

100 µg

Uses :

Immunocytochemistry;Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.