Amyloid Beta (ABeta) x-42 Antibody, clone 12F4 | EMD Millipore 05-831-I product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Amyloid Beta (ABeta) x-42 Antibody, clone 12F4

catalog :

05-831-I

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12F4

The same clone is also sold as:

BioLegend: 805507, 805501, 805509, 805504, 805502, 805503
Abnova: MAB4647

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 4b	Lloyd G, Trejo Lopez J, Xia Y, McFarland K, Lincoln S, Ertekin Taner N, et al. Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease. Acta Neuropathol Commun. 2020;8:31 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 4d	Ano Y, Ohya R, Takaichi Y, Washinuma T, Uchida K, Takashima A, et al. β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline. J Alzheimers Dis. 2020;73:1331-1342 pubmed publisher
immunocytochemistry; mouse; 1:50; loading ...; fig 1a	Ubelmann F, Burrinha T, Salavessa L, Gomes R, Ferreira C, Moreno N, et al. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep. 2017;18:102-122 pubmed publisher
immunocytochemistry; human; 1:2000; fig 1	Brai E, Alina Raio N, Alberi L. Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease. Acta Neuropathol Commun. 2016;4:64 pubmed publisher

product information

Catalog Number :

05-831-I

Subcategory :

Neuroscience

Product Name :

Anti-Amyloid Beta (ABeta) x-42 Antibody, clone 12F4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05067

Host Name :

Mouse

Antigen :

Amyloid Beta (ABeta) x-42

Clone :

12F4

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Amyloid Beta (ABeta) x-42 Antibody, clone 12F4

Cross Reactivity :

Human

Background :

One of the most important and initial steps which causes loss of memory and cognition in Alzheimer’s Disease (AD) involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43 amino acid peptides (Amyloid Beta) 1-40, 1-42 and 1-43). Polymerization of beta-amyloid and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition.

ALT Names :

Amyloid beta A4 protein;ABPP;APPI;APP;Alzheimer disease amyloid protein;Cerebral vascular amyloid peptide;CVAP;PreA4;Protease nexin-II;PN-II

Immunogen :

KLH-conjugated linear peptide corresponding to human Amyloid Beta (ABeta) x-42.

Specificity :

This antibody detects Amyloid Beta (ABeta) x-42, but does not cross react with Amyloid Beta (ABeta) x-40 or Amyloid Beta (Abeta) x-43.

Package Size :

100 µL

Uses :

Immunohistochemistry;Enzyme Immunoassay (ELISA)

Storage :

Stable for 1 year at 2-8°C from date of receipt