PDGFR-β Antibody, clone 4A56, rabbit monoclonal | EMD Millipore 05-825R product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PDGFR-β Antibody, clone 4A56, rabbit monoclonal

catalog :

05-825R

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

4A56

reactivity :

human, mouse

application :

western blot, immunoprecipitation

product information

Catalog Number :

05-825R

Subcategory :

Cell Signaling

Product Name :

Anti-PDGFR-β Antibody, clone 4A56, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09619

Host Name :

Rabbit

Antigen :

PDGFR-β

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-PDGFR-β Antibody, clone 4A56, rabbit monoclonal

Cross Reactivity :

Mouse;Human

Background :

PDGFR (Platelet-Derived Growth Factor Receptor) is a receptor tyrosine kinase for the PDGF family of growth factors. PDGF homo and hetero- dimmers (dimer of A (17 kDa) and B (14 kDa) chains (AA, AB, or BB)) bind to the two structurally related a and b PDGF Receptors (PDGFRa and PDGFRb). The type A PDGF Receptor binds all three PDGFs with high affinity, whereas the type B PDGF Receptor is selective for PDGF-BB. This binding results in the dimerization of the receptor and the subsequent kinase activation of the receptor tyrosine kinase (RTK) and its autophosphorylation. These phosphorylations allow for various proteins, such as PI3 Kinase, PLCg, and Grb2, to bind through their SH2 domains and transduce signals into the cell. The activation of PDGFFR triggers the intracellular loop and activates Ras, Erk1/2, and ROS. PDGFb has been implicated in embryonic development, angiogenesis, and development of tumors of glial origin.

ALT Names :

PDGF subunit B;PDGF, B chain;Platelet-derived growth factor B chain;Platelet-derived growth factor beta polypeptide;Platelet-derived growth factor, beta polypeptide (oncogene SIS);platelet-derived growth factor 2;platelet-derived growth factor beta;platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog);platelet-derived growth factor, B chain

Immunogen :

KLH-conjugated linear peptide corresponding to human PDGFR-β at the protein kinase domain.

Specificity :

This antibody recognizes PDGFR-β at the protein kinase domain.

Package Size :

100 µL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.