Meis 1/2/3 Antibody, clone 9.2.7 | EMD Millipore 05-779 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Meis 1/2/3 Antibody, clone 9.2.7

catalog :

05-779

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9.2.7

The same clone is also sold as:

Santa Cruz Biotechnology: sc-101850

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, ChIP-Seq, western blot knockout validation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; 1:100; fig 1 ChIP-Seq; mouse; fig 6	Bouilloux F, Thireau J, VentÃ©o S, Farah C, Karam S, Dauvilliers Y, et al. Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. elife. 2016;5: pubmed publisher
western blot; mouse	Zhou J, Wu J, Li B, Liu D, Yu J, Yan X, et al. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. Leukemia. 2014;28:1436-48 pubmed publisher

product information

Catalog Number :

05-779

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Meis 1/2/3 Antibody, clone 9.2.7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O14770

Host Name :

Mouse

Antigen :

Meis 1/2/3

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-Meis 1/2/3 Antibody, clone 9.2.7

Cross Reactivity :

Human;Mouse

Background :

Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Meis1, 2, and 3 are members of the TALE (three amino acid loop extension) family of homeodomain containing proteins. Meis1 binds to Hox and Pbx proteins to form complexes with distinct DNA-binding specificities. Like Hox and Pbx proteins, the overexpression of Meis1 in BHX-2 myeloid leukemias implies a role for this protein in oncogenesis. Two Meis related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and express in normal tissues as well as myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.

Immunogen :

MBP-conjugated fusion protein corresponding to amino acids 60-390 of mouse Meis1

Specificity :

Meis1, Meis2, Meis3 and splice variants

Package Size :

100 µL

Uses :

Immunoprecipitation;Western Blotting;Immunohistochemistry

Storage :

2 years at -20°C