MLL/HRX Antibody, CT., clone 9-12 | EMD Millipore 05-765 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MLL/HRX Antibody, CT., clone 9-12

catalog :

05-765

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9-12

reactivity :

human, mouse

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 11

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; loading ...; fig 3c western blot; human; 1:500; loading ...; fig 1c	Svoboda L, Bailey N, Van Noord R, Krook M, Harris A, Cramer C, et al. Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin. Oncotarget. 2017;8:458-471 pubmed publisher
chromatin immunoprecipitation; mouse; fig 1 immunoprecipitation; mouse; fig 1 western blot; mouse; fig 1	Dhawan S, Dirice E, Kulkarni R, Bhushan A. Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. Diabetes. 2016;65:1208-18 pubmed publisher
chromatin immunoprecipitation; mouse immunoprecipitation; mouse chromatin immunoprecipitation; human	Zhou J, Dhawan S, Fu H, Snyder E, Bottino R, Kundu S, et al. Combined modulation of polycomb and trithorax genes rejuvenates ? cell replication. J Clin Invest. 2013;123:4849-58 pubmed
western blot; human; 1:1000	Gallo M, Ho J, Coutinho F, Vanner R, Lee L, Head R, et al. A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Res. 2013;73:417-27 pubmed publisher
	Schwörer S, Becker F, Feller C, Baig A, Köber U, Henze H, et al. Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. Nature. 2016;540:428-432 pubmed publisher
	Maeng Y, Lee G, Choi S, Kim K, Kim E. Histone methylation levels correlate with TGFBIp and extracellular matrix gene expression in normal and granular corneal dystrophy type 2 corneal fibroblasts. BMC Med Genomics. 2015;8:74 pubmed publisher
	Duan Z, Zou J, Yang P, Wang Y, Borowsky A, Gao A, et al. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Prostate. 2013;73:455-66 pubmed publisher
	Huo H, Magro P, Pietsch E, Patel B, Scotto K. Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance. Cancer Res. 2010;70:8726-35 pubmed publisher
	Revenko A, Kalashnikova E, Gemo A, Zou J, Chen H. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol. 2010;30:5260-72 pubmed publisher
	Agherbi H, Gaussmann Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M. Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence. PLoS ONE. 2009;4:e5622 pubmed publisher
	Cho Y, Hong T, Hong S, Guo H, Yu H, Kim D, et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem. 2007;282:20395-406 pubmed

product information

Catalog Number :

05-765

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-MLL/HRX Antibody, CT., clone 9-12

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q03164

Host Name :

Mouse

Antigen :

MLL/HRX

Clone :

9-12

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MLL/HRX Antibody, CT., clone 9-12

Cross Reactivity :

Human;Mouse

Background :

The acute lymphoblastic leukaemia (ALL)-1 (also known as MLL, HRX, HTRX, and TRX1) gene on human chromosome 11q23 is the site of many locally clustered chromosomal alterations associated with several types of acute leukaemias, including deletions, partial duplications and translocations. Structurally variant proteins derived from the altered gene presumably cause the malignant transformation of early haemopoietic progenitor cells.

Immunogen :

MBP fusion protein corresponding to residues 3084-3959 of human mixed lineage leukemia (MLL)

Specificity :

Recognizes the C-terminal proteolytic fragment of MLL (MLL C ).

Package Size :

200 μg

Uses :

Chromatin Immunoprecipitation (ChIP);Western Blotting;Immunoprecipitation

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.