PML Antibody, clone 36.1-104 | EMD Millipore 05-718 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PML Antibody, clone 36.1-104

catalog :

05-718

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

36.1-104

The same clone is also sold as:

LifeSpan Biosciences: LS-C179721
Enzo Life Sciences: ALX-804-816-C100
Active Motif: 39773
Abnova: MAB3726

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunocytochemistry knockout validation

citations: 17

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry knockout validation; mouse; loading ...; fig 1a western blot; human; loading ...; fig 5c	Guarnerio J, Mendez L, Asada N, Menon A, Fung J, Berry K, et al. A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche. Nat Commun. 2018;9:66 pubmed publisher
immunocytochemistry; mouse; 1:200; fig s1	Marzahn M, Marada S, Lee J, Nourse A, Kenrick S, Zhao H, et al. Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles. EMBO J. 2016;35:1254-75 pubmed publisher
immunocytochemistry; human	Lu H, Fang E, Sykora P, Kulikowicz T, Zhang Y, Becker K, et al. Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. Cell Death Dis. 2014;5:e1226 pubmed publisher
immunocytochemistry; mouse	Münch S, Weidtkamp Peters S, Klement K, Grigaravicius P, Monajembashi S, Salomoni P, et al. The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence. Mol Cell Biol. 2014;34:1733-46 pubmed publisher
western blot; mouse	Evdokimov E, Sharma P, Lockett S, Lualdi M, Kuehn M. Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3. J Cell Sci. 2008;121:4106-13 pubmed publisher
	Salsman J, Rapkin L, Margam N, Duncan R, Bazett Jones D, Dellaire G. Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres. Cell Death Dis. 2017;8:e2724 pubmed publisher
	Ahmed A, Wan X, Mitxitorena I, Lindsay A, Paolo Pandolfi P, McCaffrey M, et al. Regulation of NF-κB by PML and PML-RARα. Sci Rep. 2017;7:44539 pubmed publisher
	Ishida K, Miyauchi K, Kimura Y, Mito M, Okada S, Suzuki T, et al. Regulation of gene expression via retrotransposon insertions and the noncoding RNA 4.5S RNAH. Genes Cells. 2015;20:887-901 pubmed publisher
	Stout G, Blasco M. Telomere length and telomerase activity impact the UV sensitivity syndrome xeroderma pigmentosum C. Cancer Res. 2013;73:1844-54 pubmed publisher
	Berscheminski J, Groitl P, Dobner T, Wimmer P, Schreiner S. The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription. J Virol. 2013;87:965-77 pubmed publisher
	Neault M, Mallette F, Vogel G, Michaud Levesque J, Richard S. Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. 2012;40:9513-21 pubmed publisher
	Campagna M, Herranz D, Garcia M, Marcos Villar L, González Santamaría J, Gallego P, et al. SIRT1 stabilizes PML promoting its sumoylation. Cell Death Differ. 2011;18:72-9 pubmed publisher
	Kennedy A, McBryan T, Enders G, Johnson F, Zhang R, Adams P. Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Div. 2010;5:16 pubmed publisher
	Cho G, Lim Y, Golden J. SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation. J Biol Chem. 2009;284:19592-600 pubmed publisher
	Gupta P, Ho P, Ha S, Lin Y, Wei L. HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. PLoS ONE. 2009;4:e4363 pubmed publisher
	Regad T, Bellodi C, Nicotera P, Salomoni P. The tumor suppressor Pml regulates cell fate in the developing neocortex. Nat Neurosci. 2009;12:132-40 pubmed publisher
	Kim T, Lee J, Oh S, Jin X, Choi Y, Lee T, et al. Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. Cancer Res. 2007;67:11133-40 pubmed

product information

Catalog Number :

05-718

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-PML Antibody, clone 36.1-104

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P29590

Host Name :

Mouse

Antigen :

PML

Clone :

36.1-104

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-PML Antibody, clone 36.1-104

Cross Reactivity :

Mouse

Background :

Promyeloctic Leukemia Gene product (PML) is a nuclear protein with growth-suppressive properties originally identified in the context of the PML-retinoic receptor alpha (RAR alpha) fusion protein of acute promyelocytic leukemia. PML localizes within distinct nuclear structures, called nuclear bodies, which are disrupted by the expression of PML-RAR alpha.

Immunogen :

6His fusion protein corresponding to mouse PML (promyelocytic leukemia protein)

Specificity :

Recognizes PML.

Package Size :

200 μg

Uses :

Immunocytochemistry;Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.