Lamin A/C Antibody, clone 14 | EMD Millipore 05-714 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Lamin A/C Antibody, clone 14

catalog :

05-714

quantity :

50 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, dogs, domestic horse

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 7c	Miyoshi H, VanDussen K, Malvin N, Ryu S, Wang Y, Sonnek N, et al. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO J. 2017;36:5-24 pubmed publisher
western blot; human; fig 4	Podmirseg S, JÃ¤kel H, Ranches G, Kullmann M, Sohm B, Villunger A, et al. Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene. 2016;35:4580-90 pubmed publisher
immunohistochemistry; domestic horse; 1:100; fig 2 immunohistochemistry; human; 1:100; fig 2	Quattrocelli M, Giacomazzi G, Broeckx S, Ceelen L, Bolca S, Spaas J, et al. Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates. Stem Cell Reports. 2016;6:55-63 pubmed publisher
immunocytochemistry; human western blot; human	Tikoo S, Madhavan V, Hussain M, Miller E, Arora P, Zlatanou A, et al. Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination. EMBO J. 2013;32:1778-92 pubmed publisher
	Casciello F, Al Ejeh F, Kelly G, Brennan D, Ngiow S, Young A, et al. G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. Proc Natl Acad Sci U S A. 2017;114:7077-7082 pubmed publisher
	Floyd S, Pacold M, Huang Q, Clarke S, Lam F, Cannell I, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013;498:246-50 pubmed publisher
	Kumar P, Luo Y, Tudela C, Alexander J, Mendelson C. The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation. Mol Cell Biol. 2013;33:1782-96 pubmed publisher
	LEE G, Kim J, Taylor M, Muller M. DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair. J Biol Chem. 2010;285:37630-40 pubmed publisher
	Hamel S, Bouchard A, Ferrario C, Hassan S, Aguilar Mahecha A, Buchanan M, et al. Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers. Breast Cancer Res Treat. 2010;120:47-57 pubmed publisher
	Oehmig A, Klotzbücher A, Thomas M, Weise F, Hagner U, Brundiers R, et al. A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries. BMC Genomics. 2008;9:441 pubmed publisher

product information

Catalog Number :

05-714

Subcategory :

Cell Structure

Product Name :

Anti-Lamin A/C Antibody, clone 14

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P02545

Host Name :

Mouse

Antigen :

Lamin A/C

Clone :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Lamin A/C Antibody, clone 14

Cross Reactivity :

Human;Mouse;Rat;Canine;Chicken

Background :

Nuclear lamins are composed of the type V intermediate filament proteins. Often referred to as nucleoskeletal proteins they play a key role in nuclear integrity, positioning of nuclear pores, and overall nuclear size and shape. They also play several key functional roles in the maintenance and propagation of the genome--replication, transcription-- as well as the disassembly and reassembly of the nucleus during cell division. In vitro studies have shown that dimers are the basic building blocks of higher order lamin structures and in low concentrations lamins are distributed throughout the nucleoplasm. In humans, there are two types of lamins: A-type lamins (lamins A and C), found primarily in differentiated cells, and B-type lamins (lamins B1 and B2), found in all nucleated cells. Nuclear lamins are involved in a number of essential nuclear functions, including nuclear envelope assembly and disassembly during cell division, DNA synthesis, transcription, and apoptosis. Nuclear lamins have been found to co-localize with DNA synthesis sites.

Immunogen :

Peptide from human lamin A/C corresponding to amino acids 398 to 490.

Specificity :

Recognizes Lamin A, MW ~74 kDa and Lamin C, MW ~65 kDa.

Package Size :

50 μg

Uses :

Immunocytochemistry;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.