IGF-IR Antibody, clone JBW902 | EMD Millipore 05-656 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IGF-IR Antibody, clone JBW902

catalog :

05-656

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

JBW902

The same clone is also sold as:

LifeSpan Biosciences: LS-B2905
Abnova: MAB12559

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

citations: 9

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1a immunoprecipitation; human; loading ...; fig 1b	Beauvais D, Jung O, Yang Y, Sanderson R, Rapraeger A. Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth. Cancer Res. 2016;76:4981-93 pubmed publisher
western blot; human	Haven B, Heilig E, Donham C, Settles M, Vasilevsky N, Owen K. Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. elife. 2016;5: pubmed publisher
western blot; human	Sahin O, Frohlich H, Löbke C, Korf U, Burmester S, Majety M, et al. Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Syst Biol. 2009;3:1 pubmed publisher
	Waraky A, Lin Y, Warsito D, Haglund F, Aleem E, Larsson O. Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage. J Biol Chem. 2017;292:18227-18239 pubmed publisher
	Mroue R, Huang B, Braunstein S, Firestone A, Nakamura J. Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice. PLoS Genet. 2015;11:e1005235 pubmed publisher
	Chugh R, Griffith K, Davis E, Thomas D, Zavala J, Metko G, et al. Doxorubicin plus the IGF-1R antibody cixutumumab in soft tissue sarcoma: a phase I study using the TITE-CRM model. Ann Oncol. 2015;26:1459-64 pubmed publisher
	Craddock B, Miller W. Effects of somatic mutations in the C-terminus of insulin-like growth factor 1 receptor on activity and signaling. J Signal Transduct. 2012;2012:804801 pubmed publisher
	Cooper A, van Doorninck J, Ji L, Russell D, Ladanyi M, Shimada H, et al. Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group. Clin Cancer Res. 2011;17:56-66 pubmed publisher
	Craddock B, Cotter C, Miller W. Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region. FEBS Lett. 2007;581:3235-40 pubmed

product information

Catalog Number :

05-656

Subcategory :

Cell Signaling

Product Name :

Anti-IGF-IR Antibody, clone JBW902

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08069

Host Name :

Mouse

Antigen :

IGF-IR

Clone :

JBW902

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-IGF-IR Antibody, clone JBW902

Cross Reactivity :

Human;Mouse

Background :

There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kDa) and two beta (95 kDa) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Immunogen :

GST fusion protein corresponding to residues 1264-1367 of human IGF-1 Receptor

Specificity :

Recognizes IGF-1 receptor b chain; does not cross react with insulin receptor.

Package Size :

200 μg

Uses :

Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.