CAR Antibody, clone RmcB | EMD Millipore 05-644 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CAR Antibody, clone RmcB

catalog :

05-644

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RmcB

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry, blocking or activating experiments

citations: 34

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...	Hulin Curtis S, Davies J, Nestić D, Bates E, Baker A, Cunliffe T, et al. Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications. Cancer Gene Ther. 2020;: pubmed publisher
flow cytometry; human; 1:500; loading ...; fig 10	Fielding C, Weekes M, Nobre L, Růcková E, Wilkie G, Paulo J, et al. Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation. elife. 2017;6: pubmed publisher
flow cytometry; human; tbl 3	Kaliberov S, Kaliberova L, Yan H, Kapoor V, Hallahan D. Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther. 2016;23:303-14 pubmed publisher
blocking or activating experiments; human; 1:100	Lenman A, Liaci A, Liu Y, Årdahl C, Rajan A, Nilsson E, et al. Human adenovirus 52 uses sialic acid-containing glycoproteins and the coxsackie and adenovirus receptor for binding to target cells. PLoS Pathog. 2015;11:e1004657 pubmed publisher
flow cytometry; human	Majhen D, Stojanović N, Vukić D, Pichon C, Leduc C, Osmak M, et al. Increased adenovirus Type 5 mediated transgene expression due to RhoB down-regulation. PLoS ONE. 2014;9:e86698 pubmed publisher
flow cytometry; human	Janssen J, Liu J, Skokan J, Gonçalves M, de Vries A. Development of an AdEasy-based system to produce first- and second-generation adenoviral vectors with tropism for CAR- or CD46-positive cells. J Gene Med. 2013;15:1-11 pubmed publisher
flow cytometry; human; 1:250	Kasman L, Lu P, Voelkel Johnson C. The histone deacetylase inhibitors depsipeptide and MS-275, enhance TRAIL gene therapy of LNCaP prostate cancer cells without adverse effects in normal prostate epithelial cells. Cancer Gene Ther. 2007;14:327-34 pubmed
	Yamauchi S, Zhong B, Kawamura K, Yang S, Kubo S, Shingyoji M, et al. Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes. BMC Cancer. 2017;17:622 pubmed publisher
	Marroquí L, Lopes M, dos Santos R, Grieco F, Roivainen M, Richardson S, et al. Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic Î± and Î² cells. elife. 2015;4:e06990 pubmed publisher
	Zhan Y, Yu B, Wang Z, Zhang Y, Zhang H, Wu H, et al. A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells. Int J Clin Exp Pathol. 2014;7:2850-60 pubmed
	Kaliberov S, Kaliberova L, Buggio M, Tremblay J, Shoemaker C, Curiel D. Adenoviral targeting using genetically incorporated camelid single variable domains. Lab Invest. 2014;94:893-905 pubmed publisher
	Salinas S, Zussy C, Loustalot F, Henaff D, Menendez G, Morton P, et al. Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting. J Biol Chem. 2014;289:680-95 pubmed publisher
	Zhang X, Zheng Z, Shu B, Liu X, Zhang Z, Liu Y, et al. Human astrocytic cells support persistent coxsackievirus B3 infection. J Virol. 2013;87:12407-21 pubmed publisher
	Markel D, Lam E, Harste G, Darr S, Ramke M, Heim A. Type dependent patterns of human adenovirus persistence in human T-lymphocyte cell lines. J Med Virol. 2014;86:785-94 pubmed publisher
	Parker A, White K, Lavery C, Custers J, Waddington S, Baker A. Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction. Gene Ther. 2013;20:1158-64 pubmed publisher
	Yanagawa Matsuda A, Kitamura T, Higashino F, Yamano S, Totsuka Y, Shindoh M. E1A expression might be controlled by miR-214 in cells with low adenovirus productivity. Virus Res. 2012;170:85-90 pubmed publisher
	Teigler J, Iampietro M, Barouch D. Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeys. J Virol. 2012;86:9590-8 pubmed publisher
	Kolawole A, Sharma P, Yan R, Lewis K, Xu Z, Hostetler H, et al. The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the coxsackievirus and adenovirus receptor. J Virol. 2012;86:9244-54 pubmed publisher
	Murphy A, Besmer D, Moerdyk Schauwecker M, Moestl N, Ornelles D, Mukherjee P, et al. Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. J Virol. 2012;86:3073-87 pubmed publisher
	Zhai Z, Wang Z, Fu S, Lu J, Wang F, Li R, et al. Antitumor effects of bladder cancer-specific adenovirus carrying E1A-androgen receptor in bladder cancer. Gene Ther. 2012;19:1065-74 pubmed publisher
	Yoon J, Jekle A, Najafi R, Ruado F, Zuck M, KHOSROVI B, et al. Virucidal mechanism of action of NVC-422, a novel antimicrobial drug for the treatment of adenoviral conjunctivitis. Antiviral Res. 2011;92:470-8 pubmed publisher
	Borovjagin A, Dong J, Passineau M, Ren C, Lamani E, Mamaeva O, et al. Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells. PLoS ONE. 2011;6:e24281 pubmed publisher
	Adamson R, Frazier A, Evans H, Chambers K, Schenk E, Essand M, et al. In vitro primary cell culture as a physiologically relevant method for preclinical testing of human oncolytic adenovirus. Hum Gene Ther. 2012;23:218-30 pubmed publisher
	Renois F, Hong S, Le Naour R, Gafa V, Talmud D, Andreoletti L, et al. Development of a recombinant CHO cell model for the investigation of CAR and DAF role during early steps of echovirus 6 infection. Virus Res. 2011;158:46-54 pubmed publisher
	Lewis T, Glasgow J, Glandon A, Curiel D, Standaert D. Transduction of brain dopamine neurons by adenoviral vectors is modulated by CAR expression: rationale for tropism modified vectors in PD gene therapy. PLoS ONE. 2010;5: pubmed publisher
	Botta G, Perruolo G, Libertini S, Cassese A, Abagnale A, Beguinot F, et al. PED/PEA-15 modulates coxsackievirus-adenovirus receptor expression and adenoviral infectivity via ERK-mediated signals in glioma cells. Hum Gene Ther. 2010;21:1067-76 pubmed publisher
	Liu X, Li J, Tian Y, Xu P, Chen X, Xie K, et al. Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide. Hum Gene Ther. 2010;21:157-70 pubmed publisher
	Sandberg L, Papareddy P, Silver J, Bergh A, Mei Y. Replication-competent Ad11p vector (RCAd11p) efficiently transduces and replicates in hormone-refractory metastatic prostate cancer cells. Hum Gene Ther. 2009;20:361-73 pubmed publisher
	Vigl B, Zgraggen C, Rehman N, Banziger Tobler N, Detmar M, Halin C. Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro. Exp Cell Res. 2009;315:336-47 pubmed publisher
	Nilsson E, Jamshidi F, Johansson S, Oberste M, Arnberg N. Sialic acid is a cellular receptor for coxsackievirus A24 variant, an emerging virus with pandemic potential. J Virol. 2008;82:3061-8 pubmed publisher
	Satoh M, Wang H, Ishidoya S, Abe H, Moriya T, Hamada H, et al. Oncolytic virotherapy for prostate cancer by E1A, E1B mutant adenovirus. Urology. 2007;70:1243-8 pubmed
	Hakkarainen T, Sarkioja M, Lehenkari P, Miettinen S, Ylikomi T, Suuronen R, et al. Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors. Hum Gene Ther. 2007;18:627-41 pubmed
	Reimer D, Steppan I, Wiedemair A, Concin N, Hofstetter G, Marth C, et al. Soluble isoforms but not the transmembrane form of coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancer. Int J Cancer. 2007;120:2568-75 pubmed
	Nielsen R, Grøntved L, Stunnenberg H, Mandrup S. Peroxisome proliferator-activated receptor subtype- and cell-type-specific activation of genomic target genes upon adenoviral transgene delivery. Mol Cell Biol. 2006;26:5698-714 pubmed

product information

Catalog Number :

05-644

Subcategory :

Cell Structure

Product Name :

Anti-CAR Antibody, clone RmcB

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P78310

Host Name :

Mouse

Antigen :

CAR

Clone :

RmcB

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-CAR Antibody, clone RmcB

Cross Reactivity :

Human;Mouse;Rat

Background :

The coxsackievirus and adenovirus receptor (CAR) mediates cell attachment and infection by coxsackie B viruses and by a number of adenoviruses. CAR also mediates homotypic intercellular interactions. In polarized epithelial cells, CAR is closely associated with the tight junction, where it contributes to the barrier to paracellular flow of solutes and macromolecules. CAR's biological roles are not well defined, but emerging evidence suggests that it may function during embryonic development and in regulating cell proliferation.

ALT Names :

46 kD coxsackievirus and adenovirus receptor (CAR) protein;CVB3 binding protein;CVB3-binding protein;Coxsackievirus B-adenovirus receptor;coxsackie virus B receptor;coxsackie virus and adenovirus receptor

Immunogen :

Native human coxsackie virus-adenovirus receptor protein.

Specificity :

Recognizes CAR at MW ~46 kDa.

Package Size :

200 μg

Uses :

Immunocytochemistry;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt