This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
phospho-Histone H2A.X (Ser139) Antibody, clone JBW301
catalog :
05-636-I
quantity :
200 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
JBW301
reactivity :
Tetrahymena thermophila, hamsters, human, mouse, rat, chicken, bovine, cat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 549
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 5a
de Jong M, Langendonk M, Reitsma B, Herbers P, Lodewijk M, Nijland M, et al. WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma. Ther Adv Hematol. 2020;11:2040620719898373 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3s1a
Hayes M, Ward S, Crawford G, Seoane R, Jackson W, Kipling D, et al. Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. elife. 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig 1j
Pfeifer M, Brem R, Lippert T, Boulianne B, Ho H, Robinson M, et al. SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors. J Immunol. 2019;202:3423-3433 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 1d
Anglada T, Repullès J, Espinal A, Labarge M, Stampfer M, Genesca A, et al. Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect. Aging (Albany NY). 2019;11:1510-1523 pubmed publisher
  • immunocytochemistry; human; loading ...; fig e1f, e6a
Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s3a
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Zhao Y, Tan M, Liu X, Xiong X, Sun Y. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death Dis. 2018;9:145 pubmed publisher
  • immunocytochemistry; rat; 1:2000; fig 1d
  • immunocytochemistry; human; 1:2000; loading ...; fig 1d
Welty S, Teng Y, Liang Z, Zhao W, Sanders L, Greenamyre J, et al. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. J Biol Chem. 2018;293:1353-1362 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 1b
  • western blot; human; 1:5000; loading ...; fig s1b
Natale F, Rapp A, Yu W, Maiser A, Harz H, Scholl A, et al. Identification of the elementary structural units of the DNA damage response. Nat Commun. 2017;8:15760 pubmed publisher
  • western blot; human; loading ...; fig 6
Horn A, Celic I, Dong C, Martirosyan I, Han J. A conserved role for the ESCRT membrane budding complex in LINE retrotransposition. PLoS Genet. 2017;13:e1006837 pubmed publisher
  • western blot; mouse; fig 4b
Marks D, Thomas R, Chin Y, Shah R, Khoo C, Benezra R. Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit. Cell Rep. 2017;19:1832-1845 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6
Cottineau J, Kottemann M, Lach F, Kang Y, Vély F, Deenick E, et al. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. 2017;127:1991-2006 pubmed publisher
  • western blot; mouse; loading ...; fig 6e
Li X, Eberhardt A, Hansen J, Bohmann D, Li H, Schor N. Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies. FASEB J. 2017;31:2327-2339 pubmed publisher
  • immunocytochemistry; mouse; fig 2d
Pajalunga D, Franzolin E, Stevanoni M, Zribi S, Passaro N, Gurtner A, et al. A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells. Cell Death Differ. 2017;24:774-784 pubmed publisher
  • immunohistochemistry; human; 1:800; loading ...; fig 4e
  • western blot; human; loading ...; fig 4b
Meisenberg C, Ashour M, El Shafie L, Liao C, Hodgson A, Pilborough A, et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45:1159-1176 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 2d
Gong Y, Handa N, Kowalczykowski S, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev. 2017;31:46-58 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 2a
Tumini E, Barroso S, Calero C, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. 2016;6:38873 pubmed publisher
  • immunohistochemistry; human; fig 3d
Rizzo A, Iachettini S, Salvati E, Zizza P, Maresca C, D Angelo C, et al. SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage. Nucleic Acids Res. 2017;45:1820-1834 pubmed publisher
  • western blot; human; loading ...; fig 5a
Jo U, Cai W, Wang J, Kwon Y, D Andrea A, Kim H. PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. PLoS Genet. 2016;12:e1006465 pubmed publisher
  • immunohistochemistry - paraffin section; cat; 1:50; fig 3d
Poncelet L, Garigliany M, Ando K, Franssen M, Desmecht D, Brion J. Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus. Cell Cycle. 2016;15:3482-3489 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4b
Balmus G, Barros A, Wijnhoven P, Lescale C, Hasse H, Boroviak K, et al. Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016;30:2152-2157 pubmed
  • immunohistochemistry - frozen section; mouse; loading ...; fig 6b
  • immunocytochemistry; mouse; 1:100; fig 4b
  • western blot; mouse; 1:1000; fig 5d
Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, et al. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016;126:4417-4429 pubmed publisher
  • immunohistochemistry; human; 1:1000; fig 3f
Kotsantis P, Silva L, Irmscher S, Jones R, Folkes L, Gromak N, et al. Increased global transcription activity as a mechanism of replication stress in cancer. Nat Commun. 2016;7:13087 pubmed publisher
  • immunocytochemistry; mouse; 1:10,000; fig 5
Li M, Cole F, Patel D, Misenko S, Her J, Malhowski A, et al. 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. EMBO Rep. 2016;17:1532-1541 pubmed
  • western blot; mouse; 1:3000; fig 5g
Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016;6:31895 pubmed publisher
  • immunocytochemistry; human; fig 4
Murakami Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, et al. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016;6:31615 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6b
Sloan E, Orr A, Everett R. MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus. J Virol. 2016;90:8621-33 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 8b
  • western blot; human; 1:2000; loading ...; fig 8a
He M, Lin Y, Tang Y, Liu Y, Zhou W, Li C, et al. miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells. Aging (Albany NY). 2016;8:1442-56 pubmed publisher
  • western blot; chicken; fig s4
Romanello M, Schiavone D, Frey A, Sale J. Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA. EMBO J. 2016;35:1452-64 pubmed publisher
  • immunocytochemistry; human; 1:3000; fig 5
Jullien D, Vignard J, Fedor Y, Bery N, Olichon A, Crozatier M, et al. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. J Cell Sci. 2016;129:2673-83 pubmed publisher
  • immunohistochemistry; rat; 1:50; loading ...; fig 2a
Manchon J, DABAGHIAN Y, Uzor N, Kesler S, Wefel J, Tsvetkov A. Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons. Sci Rep. 2016;6:25705 pubmed publisher
  • immunocytochemistry; human; 1:500
  • western blot; human; 1:500; loading ...; fig 3d
Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed publisher
  • immunocytochemistry; human; fig 5
Huang C, Cheng J, Bawa Khalfe T, Yao X, Chin Y, Yeh E. SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. Cell Rep. 2016;15:147-157 pubmed publisher
  • immunocytochemistry; human; fig 5
Liu J, Sun X, Zhu H, Qin Q, Yang X, Sun X. Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma. J Biochem. 2016;160:195-204 pubmed
  • immunocytochemistry; Tetrahymena thermophila; 1:100; fig 5
Xu Q, Wang R, Ghanam A, Yan G, Miao W, Song X. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein Cell. 2016;7:236-249 pubmed publisher
  • western blot; human; fig 4
Sears C, Cooney S, Chin Sinex H, Mendonca M, Turchi J. DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA Repair (Amst). 2016;40:35-46 pubmed publisher
  • immunocytochemistry; chicken; 1:1000; loading ...; fig 1b
Daly O, Gaboriau D, Karakaya K, King S, Dantas T, Lalor P, et al. CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity. J Cell Sci. 2016;129:1769-74 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1n
Chen S, FORRESTER W, Lahav G. Schedule-dependent interaction between anticancer treatments. Science. 2016;351:1204-8 pubmed publisher
  • western blot; human; fig s1
Köhler C, Koalick D, Fabricius A, Parplys A, Borgmann K, Pospiech H, et al. Cdc45 is limiting for replication initiation in humans. Cell Cycle. 2016;15:974-85 pubmed publisher
  • immunohistochemistry; mouse
Davies B, Hatton E, Altemose N, Hussin J, Pratto F, Zhang G, et al. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 2016;530:171-176 pubmed publisher
  • immunocytochemistry; human; fig 1d
Sun Y, Zhu D, Chen F, Qian M, Wei H, Chen W, et al. SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment. Oncogene. 2016;35:4321-34 pubmed publisher
  • chromatin immunoprecipitation; human; fig 5c
  • immunocytochemistry; human; fig 4a
García Rubio M, Pérez Calero C, Barroso S, Tumini E, Herrera Moyano E, Rosado I, et al. The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. PLoS Genet. 2015;11:e1005674 pubmed publisher
  • western blot; human; fig 7
Bélanger F, Angers J, Fortier Ã, Hammond Martel I, Costantino S, Drobetsky E, et al. Mutations in Replicative Stress Response Pathways Are Associated with S Phase-specific Defects in Nucleotide Excision Repair. J Biol Chem. 2016;291:522-37 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5b
Herriott A, Tudhope S, Junge G, Rodrigues N, Patterson M, Woodhouse L, et al. PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia. Oncotarget. 2015;6:43978-91 pubmed publisher
  • immunocytochemistry; human; fig s1
Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Cohen I, Idan C, Rider P, Peleg R, Vornov E, Elena V, et al. IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep. 2015;5:14756 pubmed publisher
  • immunocytochemistry; human; fig 1
Castella M, Jacquemont C, Thompson E, Yeo J, Cheung R, Huang J, et al. FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2. PLoS Genet. 2015;11:e1005563 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 6a
Kleiner R, Verma P, Molloy K, Chait B, Kapoor T. Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response. Nat Chem Biol. 2015;11:807-14 pubmed publisher
  • immunocytochemistry; human; 1:2000; fig 3
  • immunocytochemistry; mouse; 1:2000; fig 1
  • western blot; mouse; 1:1000; fig s7
Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, et al. MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. Genes Dev. 2015;29:1955-68 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000
Lohse I, Borgida A, Cao P, Cheung M, Pintilie M, Bianco T, et al. BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts. Br J Cancer. 2015;113:425-32 pubmed publisher
  • immunocytochemistry; human; 1:100
Schraivogel D, Schindler S, Danner J, Kremmer E, Pfaff J, Hannus S, et al. Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels. Nucleic Acids Res. 2015;43:7447-61 pubmed publisher
  • western blot; mouse; fig 5
Wang J, Chen S, Sun C, Chien T, Chern Y. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. 2016;35:1657-70 pubmed publisher
  • western blot; human; fig 4
Neumann J, Yang Y, Köhler R, Giaisi M, Witzens Harig M, Liu D, et al. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest. Int J Cancer. 2015;137:2739-48 pubmed publisher
  • western blot; human; 1:200; fig 6
Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher
  • western blot; human; 1:1000; fig s12
Pang B, de Jong J, Qiao X, Wessels L, Neefjes J. Chemical profiling of the genome with anti-cancer drugs defines target specificities. Nat Chem Biol. 2015;11:472-80 pubmed publisher
  • immunocytochemistry; bovine; fig 3
Koike M, Yutoku Y, Koike A. Dynamic changes in subcellular localization of cattle XLF during cell cycle, and focus formation of cattle XLF at DNA damage sites immediately after irradiation. J Vet Med Sci. 2015;77:1109-14 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 7
Zhao Y, Xiao Z, Chen W, Yang J, Li T, Fan B. Disulfiram sensitizes pituitary adenoma cells to temozolomide by regulating O6-methylguanine-DNA methyltransferase expression. Mol Med Rep. 2015;12:2313-22 pubmed publisher
  • immunocytochemistry; human; fig 5
Prickaerts P, Niessen H, Dahlmans V, Spaapen F, Salvaing J, Vanhove J, et al. MK3 modulation affects BMI1-dependent and independent cell cycle check-points. PLoS ONE. 2015;10:e0118840 pubmed publisher
  • immunocytochemistry; mouse; fig s8
  • western blot; mouse; 1:1000; fig 3
Boersma V, Moatti N, Segura Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-540 pubmed publisher
  • western blot; human; loading ...; fig s6a
Sato M, Rodríguez Barrueco R, Yu J, Do C, Silva J, Gautier J. MYC is a critical target of FBXW7. Oncotarget. 2015;6:3292-305 pubmed
  • immunohistochemistry; human; fig s3
Gibbs Seymour I, Markiewicz E, Bekker Jensen S, Mailand N, Hutchison C. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage. Aging Cell. 2015;14:162-9 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 3
La Sala G, Marazziti D, Di Pietro C, Golini E, Matteoni R, Tocchini Valentini G. Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015;29:2059-69 pubmed publisher
  • immunocytochemistry; human; 1:500
Newman E, Lu F, Bashllari D, Wang L, Opipari A, Castle V. Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma. Mol Cancer Res. 2015;13:470-82 pubmed publisher
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 6
Butin Israeli V, Adam S, Jain N, Otte G, Neems D, Wiesmüller L, et al. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015;35:884-98 pubmed publisher
  • immunocytochemistry; human; 1:500
Ciccia A, Huang J, Izhar L, Sowa M, Harper J, Elledge S. Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Proc Natl Acad Sci U S A. 2014;111:18631-6 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 5
Gabriel D, Roedl D, Gordon L, Djabali K. Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. Aging Cell. 2015;14:78-91 pubmed publisher
  • immunocytochemistry; human; 1:100
Brownlow N, Pike T, Zicha D, Collinson L, Parker P. Mitotic catenation is monitored and resolved by a PKCε-regulated pathway. Nat Commun. 2014;5:5685 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 4a
Alagpulinsa D, Ayyadevara S, SHMOOKLER REIS R. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol. 2014;4:289 pubmed publisher
  • immunocytochemistry; human; 1:1000
Harada A, Matsuzaki K, Takeiri A, Mishima M. The predominant role of apoptosis in γH2AX formation induced by aneugens is useful for distinguishing aneugens from clastogens. Mutat Res Genet Toxicol Environ Mutagen. 2014;771:23-9 pubmed publisher
  • immunoprecipitation; hamsters
  • immunocytochemistry; hamsters
  • western blot; hamsters
  • western blot; human
Kononenko A, Bansal R, Lee N, Grimes B, Masumoto H, Earnshaw W, et al. A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Res. 2014;42: pubmed publisher
  • western blot; mouse
  • western blot; human
Vassilopoulos A, Tominaga Y, Kim H, Lahusen T, Li B, Yu H, et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015;34:3023-35 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Carlessi L, Fusar Poli E, Bechi G, Mantegazza M, Pascucci B, Narciso L, et al. Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency. Cell Death Dis. 2014;5:e1342 pubmed publisher
  • immunocytochemistry; chicken
Gao C, Bourke E, Scobie M, Famme M, Koolmeister T, Helleday T, et al. Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Sci Rep. 2014;4:5372 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 4a
Katyal S, Lee Y, Nitiss K, Downing S, Li Y, Shimada M, et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014;17:813-21 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Vidi P, Liu J, Salles D, Jayaraman S, Dorfman G, Gray M, et al. NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks. Nucleic Acids Res. 2014;42:6365-79 pubmed publisher
  • western blot; mouse; 1:1000
Storm M, Kumpfmueller B, Bone H, Buchholz M, Sanchez Ripoll Y, Chaudhuri J, et al. Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells. PLoS ONE. 2014;9:e89821 pubmed publisher
  • immunocytochemistry; human
Morales J, Richard P, Rommel A, Fattah F, Motea E, Patidar P, et al. Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Res. 2014;42:4996-5006 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 3d
Murakami Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris J, Ichikawa H, et al. Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell Cycle. 2014;13:1115-31 pubmed publisher
  • immunocytochemistry; mouse
Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sörensen Zender I, et al. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS ONE. 2014;9:e88071 pubmed publisher
  • western blot; human
Belanger F, Rajotte V, Drobetsky E. A majority of human melanoma cell lines exhibits an S phase-specific defect in excision of UV-induced DNA photoproducts. PLoS ONE. 2014;9:e85294 pubmed publisher
  • immunocytochemistry; human; 1:800
Ferlazzo M, Sonzogni L, Granzotto A, Bodgi L, Lartin O, Devic C, et al. Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates. Mol Neurobiol. 2014;49:1200-11 pubmed publisher
  • immunocytochemistry; human
Frame F, Pellacani D, Collins A, Simms M, Mann V, Jones G, et al. HDAC inhibitor confers radiosensitivity to prostate stem-like cells. Br J Cancer. 2013;109:3023-33 pubmed publisher
  • immunocytochemistry; human
Hu L, Filippakis H, Huang H, Yen T, Gjoerup O. Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen. J Virol. 2013;87:13179-92 pubmed publisher
  • immunocytochemistry; human; 1:2000
Chen Y, Kamili A, Hardy J, Groblewski G, Khanna K, Byrne J. Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 2013;12:3083-97 pubmed publisher
  • western blot; mouse; 1:2500
Rass E, Chandramouly G, Zha S, Alt F, Xie A. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem. 2013;288:7086-95 pubmed publisher
  • western blot; mouse
Lin R, Ho C, Liu L, Lyu Y. Topoisomerase II? deficiency enhances camptothecin-induced apoptosis. J Biol Chem. 2013;288:7182-92 pubmed publisher
  • immunocytochemistry; mouse
Zimmermann M, Lottersberger F, Buonomo S, Sfeir A, de Lange T. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science. 2013;339:700-4 pubmed publisher
  • immunocytochemistry; human; 1:1000
Wu L, Shao L, Li M, Zheng J, Wang J, Feng W, et al. BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks. Radiat Res. 2013;179:160-70 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Jullien L, Mestre M, Roux P, Gire V. Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response. Nucleic Acids Res. 2013;41:900-11 pubmed publisher
  • immunocytochemistry; human
Solarczyk K, Zarebski M, Dobrucki J. Inducing local DNA damage by visible light to study chromatin repair. DNA Repair (Amst). 2012;11:996-1002 pubmed publisher
  • flow cytometry; human
  • immunocytochemistry; human
Coffey K, Blackburn T, Cook S, Golding B, Griffin R, Hardcastle I, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS ONE. 2012;7:e45539 pubmed publisher
  • immunocytochemistry; mouse; 1:500
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed publisher
  • immunocytochemistry; human; 1:400
Stoepker C, Hain K, Schuster B, Hilhorst Hofstee Y, Rooimans M, Steltenpool J, et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 2011;43:138-41 pubmed publisher
  • flow cytometry; human
Mao F, Sidorova J, Lauper J, Emond M, Monnat R. The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage. Cancer Res. 2010;70:6548-55 pubmed publisher
  • immunocytochemistry; human; fig 2
Sakasai R, Teraoka H, Takagi M, Tibbetts R. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem. 2010;285:15201-8 pubmed publisher
  • immunocytochemistry; human
Sakasai R, Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem. 2008;283:13549-55 pubmed publisher
Bashir S, Dang T, Rossius J, Wolf J, Kühn R. Enhancement of CRISPR-Cas9 induced precise gene editing by targeting histone H2A-K15 ubiquitination. BMC Biotechnol. 2020;20:57 pubmed publisher
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product information
Catalog Number :
05-636-I
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P16104
Host Name :
Mouse
Antigen :
phospho-Histone H2A.X (Ser139)
Clone :
JBW301
Conjugate :
Purified
Isotype :
IgG1κ
Product Description :
Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301
Cross Reactivity :
Human;Mouse;Rat
Background :
The histone H2A.X protein is a variant member of the H2A family of histones that is distinguished from other H2A histones by a unique carboxy-terminal sequence. This unique sequence is highly conserved throughout eukaryotic evolution and is rapidly phosphorylated by ATM or ATR at the fourth residue from the carboxy-terminus (Serine 139 in mammalian H2A.X) in response to DNA double-strand breaks (DSBs). Phosphorylation of H2A.X is important in the formation of a stable repair complex at the site of DNA damage. H2A.X phosphorylation is a very rapid response to DNA damage, occurring within as little as one minute after exposure to ionizing radiation. Phosphorylation of H2A.X occurs irrespective of the cause of the DNA DSBs and phospho-H2A.X has been observed in response to environmental stresses that result in DSBs as well as programmed cellular events, including DNA rearrangement and apoptosis.
ALT Names :
Histone H2A.x;H2a/x;H2A.XS139p;H2AXS139p
Immunogen :
KLH-conjugated linear peptide corresponding to human phospho-Histone H2A. X (Ser139).
Package Size :
200 μg
Uses :
Western Blotting;Immunocytochemistry;Chromatin Immunoprecipitation (ChIP);Immunofluorescence
Storage :
Stable for 1 year at 2-8°C from date of receipt
company information
EMD Millipore
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888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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