phospho Histone H2A.X (Ser139), clone JBW301, Alexa Fluor® 488 Conjugate | EMD Millipore 05-636-AF488 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho Histone H2A.X (Ser139), clone JBW301, Alexa Fluor® 488 Conjugate

catalog :

05-636-AF488

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

AF488

antigen modification :

phosphorylated

clone name :

JBW301

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse	Davies B, Hatton E, Altemose N, Hussin J, Pratto F, Zhang G, et al. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 2016;530:171-176 pubmed publisher
immunocytochemistry; mouse; fig 1	Cohen I, Idan C, Rider P, Peleg R, Vornov E, Elena V, et al. IL-1Î± is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep. 2015;5:14756 pubmed publisher
	Liang J, Zhao H, Diplas B, Liu S, Liu J, Wang D, et al. Genome-wide CRISPR-Cas9 screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition. Cancer Res. 2019;: pubmed publisher

product information

Catalog Number :

05-636-AF488

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho Histone H2A.X (Ser139), clone JBW301, Alexa Fluor® 488 Conjugate

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P16104

Host Name :

Mouse

Antigen :

H2AFX

Clone :

JBW301

Conjugate :

AlexaFluor®488

Purification Method :

Protein G purified

Isotype :

IgG1

Product Description :

Anti-phospho Histone H2A.X (Ser139), clone JBW301, Alexa Fluor® 488 Conjugate

Cross Reactivity :

Human

Background :

Histone H2A.X is a variant of histone H2A, and is similarly associated with genomic DNA. However, histone is structurally different from other members of the H2A family in possessing a C-terminal tail that contains the Ser139 residue that is phosphorylated in response to breaks in double-stranded DNA. The phosphorylation of H2A.X is a rapid process that is mediated by ATM/ATR proteins.

ALT Names :

Histone H2AX, H2a/x, Histone H2A.X

Immunogen :

Linear peptide corresponding to phospho-Histone H2A.X (Ser139).

Package Size :

100 µL

Uses :

Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt